|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
phosphorylation
|
|
gptkbp:alsoKnownAs
|
gptkb:ERK2
gptkb:MAPK1
|
|
gptkbp:discoveredBy
|
1991
|
|
gptkbp:encodedBy
|
gptkb:MAPK1_gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.24
|
|
gptkbp:function
|
signal transduction
regulation of cell proliferation
regulation of cell survival
regulation of differentiation
|
|
gptkbp:gene
|
gptkb:MAPK1
|
|
gptkbp:GO
|
GO:0000165
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p42 MAPK
|
|
gptkbp:inhibitedBy
|
gptkb:PD98059
gptkb:U0126
|
|
gptkbp:interactsWith
|
gptkb:ELK1
gptkb:MNK1
gptkb:c-Myc
gptkb:DUSP6
gptkb:RSK1
gptkb:c-Fos
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
cellular response to growth factors
cellular response to stress
cellular response to cytokines
|
|
gptkbp:length
|
360 amino acids
|
|
gptkbp:locatedOnChromosome
|
22q11.22
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:ERK_subfamily
|
|
gptkbp:molecularWeight
|
42 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:2ERK
|
|
gptkbp:phosphorylates
|
gptkb:MEK1
gptkb:MEK2
Thr185
Tyr187
|
|
gptkbp:relatedTo
|
gptkb:ERK1
gptkb:p44_MAPK
|
|
gptkbp:role
|
gptkb:cancer
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:structure
|
serine/threonine kinase
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P28482
|
|
gptkbp:bfsParent
|
gptkb:ERK
|
|
gptkbp:bfsLayer
|
6
|