|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:C-FOS
gptkb:FOS_proto-oncogene
gptkb:G0S7
gptkb:AP-1
|
|
gptkbp:alternativeName
|
gptkb:Proto-oncogene_c-Fos
gptkb:AP-1_transcription_factor_subunit_c-Fos
|
|
gptkbp:associatedWith
|
gptkb:cancer
osteosarcoma
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:encodes
|
gptkb:c-Fos_protein
|
|
gptkbp:Entrez_Gene_ID
|
2353
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:form
|
AP-1 transcription factor complex
|
|
gptkbp:formsComplexWith
|
gptkb:JUN_proteins
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:3796
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FOS gene
|
|
gptkbp:involvedIn
|
apoptosis
cell proliferation
differentiation
|
|
gptkbp:length
|
380 amino acids
|
|
gptkbp:locatedOnChromosome
|
14q24.3
|
|
gptkbp:memberOf
|
gptkb:FOS_gene_family
|
|
gptkbp:mRNA
|
gptkb:NM_005252
|
|
gptkbp:mutationAssociatedWith
|
can lead to abnormal cell growth
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mus musculus (mouse)
Rattus norvegicus (rat)
|
|
gptkbp:product
|
gptkb:c-Fos
|
|
gptkbp:regulates
|
inducible by cytokines
inducible by growth factors
inducible by stress
regulated by ERK pathway
regulated by JNK pathway
regulated by MAPK pathway
regulated by calcium signaling
|
|
gptkbp:sequence
|
4 exons
|
|
gptkbp:significance
|
biomarker for neuronal activity
marker for immediate early gene response
|
|
gptkbp:UniProtID
|
P01100
|
|
gptkbp:bfsParent
|
gptkb:transcription_factor_Myb
|
|
gptkbp:bfsLayer
|
7
|