AP-1 transcription factor subunit c-Fos

URI: https://gptkb.org/entity/AP-1_transcription_factor_subunit_c-Fos
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alias gptkb:Proto-oncogene_c-Fos
gptkb:FOS
AP-1 complex subunit c-Fos
gptkbp:associatedWith gptkb:cancer
osteosarcoma
gptkbp:discoveredIn 1980s
gptkbp:domain basic leucine zipper domain
gptkbp:encodedBy gptkb:FOS_gene
gptkbp:Entrez_Gene_ID 2353
gptkbp:expressedIn gptkb:cancer
brain
liver
various tissues
gptkbp:formsComplexWith gptkb:c-Jun
gptkb:JunD
gptkb:JunB
gptkbp:function apoptosis
cell differentiation
cell proliferation
transcription factor
regulation of gene expression
DNA binding
protein heterodimerization activity
gptkbp:GOProcess regulation of transcription, DNA-templated
response to stimulus
gptkbp:HGNC_ID HGNC:3796
https://www.w3.org/2000/01/rdf-schema#label AP-1 transcription factor subunit c-Fos
gptkbp:involvedIn gptkb:MAPK_signaling_pathway
signal transduction
gptkbp:locale gptkb:nucleus
gptkbp:locatedOnChromosome 14q24.3
gptkbp:molecularWeight ~62 kDa
gptkbp:OMIM 164810
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:partOf AP-1 transcription factor complex
gptkbp:PDB 1FOS
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:proteinFamily bZIP transcription factor family
gptkbp:regulates immune response
cell cycle
neuronal activity
gptkbp:reviewedBy gptkb:UniProtKB/Swiss-Prot
gptkbp:UniProtID P01100
gptkbp:bfsParent gptkb:FOS_gene
gptkb:c-Fos
gptkbp:bfsLayer 8