|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
NAD-dependent protein deacetylase sirtuin-1
SIR2 homolog 1
SIR2L1
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
metabolic regulation
|
|
gptkbp:discoveredBy
|
gptkb:Leonard_Guarente
|
|
gptkbp:encodes
|
Sirtuin 1 protein
|
|
gptkbp:Entrez_Gene_ID
|
23411
ENSG00000188976
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
adipose tissue
|
|
gptkbp:function
|
regulation of transcription
cellular response to stress
NAD-dependent deacetylase activity
regulation of aging
|
|
gptkbp:HGNC_ID
|
HGNC:14929
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SIRT1 gene
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
|
|
gptkbp:modulatedBy
|
gptkb:SRT1720
resveratrol
nicotinamide
EX-527
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:type_2_diabetes
gptkb:metabolic_syndrome
obesity
|
|
gptkbp:OMIM
|
604479
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Sirt1
|
|
gptkbp:pathway
|
insulin signaling pathway
p53 signaling pathway
FOXO signaling pathway
|
|
gptkbp:proteinFamily
|
sirtuin family
NAD-binding domain
sirtuin domain
|
|
gptkbp:regulates
|
gptkb:NF-kB
gptkb:FOXO_transcription_factors
gptkb:p53
histone acetylation
PGC-1alpha
|
|
gptkbp:species
|
conserved in mammals
|
|
gptkbp:UniProtID
|
Q96EB6
|
|
gptkbp:bfsParent
|
gptkb:SIRT1
|
|
gptkbp:bfsLayer
|
7
|