|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:abbreviation
|
gptkb:HDAC
|
|
gptkbp:actsOn
|
histones
non-histone proteins
|
|
gptkbp:class
|
gptkb:Class_III_HDAC
gptkb:Class_II_HDAC
gptkb:Class_IV_HDAC
gptkb:Class_I_HDAC
|
|
gptkbp:cofactor
|
zinc
NAD+
|
|
gptkbp:discoveredBy
|
1969
|
|
gptkbp:EC_number
|
3.5.1.98
|
|
gptkbp:encodedBy
|
HDAC genes
|
|
gptkbp:foundIn
|
prokaryotes
eukaryotes
|
|
gptkbp:function
|
regulates gene expression
removes acetyl groups from histone proteins
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Histone deacetylase
|
|
gptkbp:inhibitedBy
|
histone deacetylase inhibitors
|
|
gptkbp:involves
|
gptkb:cancer
cell cycle regulation
neurodegenerative diseases
epigenetic regulation
chromatin remodeling
|
|
gptkbp:proteinFamily
|
gptkb:HDAC10
gptkb:HDAC11
gptkb:HDAC2
gptkb:HDAC3
gptkb:HDAC4
gptkb:HDAC5
gptkb:HDAC6
gptkb:HDAC7
gptkb:HDAC8
gptkb:HDAC9
gptkb:SIRT1
gptkb:SIRT2
gptkb:SIRT3
gptkb:SIRT6
gptkb:SIRT7
gptkb:HDAC1
gptkb:SIRT4
gptkb:SIRT5
|
|
gptkbp:relatedTo
|
histone acetyltransferase
|
|
gptkbp:targetOfDrug
|
gptkb:valproic_acid
gptkb:vorinostat
gptkb:belinostat
gptkb:entinostat
gptkb:panobinostat
gptkb:romidepsin
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|