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gptkbp:instanceOf
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gptkb:protein
gptkb:gene
|
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gptkbp:alternativeName
|
MADH7
Mothers against decapentaplegic homolog 7
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gptkbp:associatedWith
|
colorectal cancer
inflammatory bowel disease
|
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gptkbp:encodes
|
Mothers against decapentaplegic homolog 7
|
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gptkbp:Entrez_Gene_ID
|
4092
ENSG00000101665
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gptkbp:expressedIn
|
various tissues
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gptkbp:function
|
inhibits TGF-beta signaling pathway
negative regulator of SMAD signaling
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gptkbp:geneType
|
protein-coding
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gptkbp:HGNC_ID
|
HGNC:6772
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|
https://www.w3.org/2000/01/rdf-schema#label
|
SMAD7
|
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gptkbp:inhibitedBy
|
TGF-beta-induced transcription
phosphorylation of receptor-regulated SMADs
|
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gptkbp:interactsWith
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:SMURF1
gptkb:SMURF2
gptkb:TGFBR1
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gptkbp:locatedOnChromosome
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gptkb:chromosome_18
|
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gptkbp:OMIM
|
602932
|
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gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
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gptkbp:regulates
|
TGF-beta receptor signaling
regulated by TGF-beta
|
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gptkbp:species
|
gptkb:Homo_sapiens
|
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gptkbp:subcellularLocation
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gptkb:nucleus
gptkb:cytoplasm
|
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gptkbp:UniProtID
|
O15105
|
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gptkbp:bfsParent
|
gptkb:SMAD4_gene
gptkb:SMAD_family
gptkb:TGF-beta_signaling_pathway
gptkb:SMAD
gptkb:SIRT1
gptkb:SMURF1
gptkb:SMURF2
gptkb:WWP1
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gptkbp:bfsLayer
|
7
|