|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:STK11
|
|
gptkbp:discoveredBy
|
Marx et al.
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:encodedBy
|
gptkb:STK11_gene
|
|
gptkbp:Entrez_Gene_ID
|
6794
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:formsComplexWith
|
MO25
STRAD
|
|
gptkbp:function
|
tumor suppressor
serine/threonine kinase
|
|
gptkbp:gene
|
gptkb:STK11
|
|
gptkbp:HGNC_ID
|
11389
|
|
gptkbp:highestExpression
|
gptkb:skeletal_muscle
liver
pancreas
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LKB1
|
|
gptkbp:involvedIn
|
energy metabolism
cell polarity
AMPK activation
|
|
gptkbp:length
|
433 amino acids
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.3
|
|
gptkbp:molecularWeight
|
48 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Peutz-Jeghers_syndrome
various cancers
|
|
gptkbp:OMIM
|
602216
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Stk11
|
|
gptkbp:orthologInYeast
|
Sak1
|
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
gptkb:Wnt_signaling_pathway
AMPK signaling pathway
|
|
gptkbp:PDB
|
1O6L
|
|
gptkbp:phosphorylates
|
gptkb:AMPK
BRSK kinases
MARK kinases
SIK kinases
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
apoptosis
cell cycle
cell metabolism
|
|
gptkbp:requires
|
embryonic development
maintenance of energy homeostasis
|
|
gptkbp:UniProtID
|
Q15831
|
|
gptkbp:bfsParent
|
gptkb:PRKAA1
gptkb:PRKAA2
gptkb:SIRT1
gptkb:STK11
gptkb:AMP-activated_protein_kinase_pathway
|
|
gptkbp:bfsLayer
|
7
|