Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
Silent information regulator 2
|
| gptkbp:cofactor |
NAD+
|
| gptkbp:discoveredBy |
gptkb:Leonard_Guarente
|
| gptkbp:encodedBy |
SIR2 gene
|
| gptkbp:enzymeCommissionNumber |
gptkb:EC_3.5.1.98
|
| gptkbp:firstDescribed |
1995
|
| gptkbp:foundIn |
gptkb:Saccharomyces_cerevisiae
|
| gptkbp:function |
regulation of transcription
histone deacetylase |
| gptkbp:gene |
gptkb:SIR2
|
| https://www.w3.org/2000/01/rdf-schema#label |
Sir2
|
| gptkbp:involvedIn |
aging
gene silencing chromatin modification |
| gptkbp:locatedOn |
gptkb:chromosome_X_(S._cerevisiae)
|
| gptkbp:memberOf |
sirtuin family
|
| gptkbp:molecularWeight |
~60 kDa
|
| gptkbp:orthologIn |
gptkb:Bacteria
mammals plants SIRT1 (human) |
| gptkbp:regulates |
HM loci silencing
rDNA recombination telomeric silencing |
| gptkbp:relatedTo |
lifespan extension in yeast
|
| gptkbp:structure |
contains sirtuin domain
|
| gptkbp:bfsParent |
gptkb:SIRT1
|
| gptkbp:bfsLayer |
7
|