Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatesTranscriptionOf |
gptkb:LDHA
gptkb:EPO gptkb:GLUT1 gptkb:VEGF |
| gptkbp:degradedBy |
gptkb:proteasome
oxygen levels |
| gptkbp:encodedBy |
gptkb:HIF1A_gene
|
| gptkbp:formsComplexWith |
HIF1β
|
| gptkbp:fullName |
gptkb:Hypoxia-inducible_factor_1-alpha
|
| gptkbp:function |
transcription factor
|
| https://www.w3.org/2000/01/rdf-schema#label |
HIF1α
|
| gptkbp:inhibitedBy |
gptkb:VHL_protein
|
| gptkbp:involvedIn |
angiogenesis
metabolic reprogramming tumor progression cellular adaptation to low oxygen |
| gptkbp:locale |
gptkb:nucleus
|
| gptkbp:locatedOnChromosome |
14q23.2
|
| gptkbp:phosphorylates |
various kinases
|
| gptkbp:postTranslationalModification |
ubiquitination
hydroxylation |
| gptkbp:regulates |
response to hypoxia
|
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:stabilizedUnder |
hypoxic conditions
|
| gptkbp:UniProtID |
Q16665
|
| gptkbp:bfsParent |
gptkb:SIRT1
|
| gptkbp:bfsLayer |
7
|