|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
resveratrol
caloric restriction
|
|
gptkbp:alternativeName
|
SIR2L1
Sirtuin (silent mating type information regulation 2 homolog) 1
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:type_2_diabetes
|
|
gptkbp:encodedBy
|
gptkb:SIRT1_gene
|
|
gptkbp:Entrez_Gene_ID
|
23411
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.5.1.98
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
adipose tissue
pancreas
|
|
gptkbp:fullName
|
gptkb:Sirtuin_1
|
|
gptkbp:function
|
gptkb:NAD-dependent_deacetylase
regulation of apoptosis
regulation of transcription
regulation of metabolism
regulation of aging
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Sirt1
|
|
gptkbp:inhibitedBy
|
nicotinamide
sirtinol
|
|
gptkbp:interactsWith
|
gptkb:FOXO_transcription_factors
gptkb:p53
gptkb:NF-κB
gptkb:PGC-1α
|
|
gptkbp:locatedOnChromosome
|
10q21.3
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
82 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
Sir2 (yeast)
|
|
gptkbp:regulates
|
cell survival
DNA repair
lipid metabolism
inflammation
insulin sensitivity
mitochondrial biogenesis
glucose homeostasis
circadian rhythm
|
|
gptkbp:UniProtID
|
Q96EB6
|
|
gptkbp:bfsParent
|
gptkb:SIRT1
|
|
gptkbp:bfsLayer
|
7
|