|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
resveratrol
caloric restriction
|
|
gptkbp:alsoKnownAs
|
gptkb:SIRT1
|
|
gptkbp:discoveredBy
|
gptkb:Leonard_Guarente
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:enzymeClassification
|
EC 2.4.2.31
|
|
gptkbp:familyMember
|
sirtuin family
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
DNA repair
regulation of apoptosis
regulation of transcription
regulation of metabolism
NAD+-dependent deacetylase
|
|
gptkbp:gene
|
gptkb:SIRT1_gene
|
|
gptkbp:HGNC_ID
|
14929
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Sirtuin 1
|
|
gptkbp:inhibitedBy
|
nicotinamide
sirtinol
|
|
gptkbp:interactsWith
|
gptkb:FOXO_transcription_factors
gptkb:p53
gptkb:NF-κB
gptkb:PGC-1α
|
|
gptkbp:length
|
747
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10q21.3
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
82 kDa
|
|
gptkbp:OMIM
|
604479
|
|
gptkbp:orthologIn
|
yeast Sir2
|
|
gptkbp:PDB
|
4I5I
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
acetylation
|
|
gptkbp:regulates
|
lipid metabolism
cellular senescence
inflammation
insulin sensitivity
mitochondrial biogenesis
stress response
circadian rhythm
energy homeostasis
|
|
gptkbp:relatedTo
|
gptkb:cancer
aging
neurodegenerative diseases
metabolic disorders
|
|
gptkbp:substrate
|
histones
non-histone proteins
|
|
gptkbp:UniProtID
|
Q96EB6
|
|
gptkbp:bfsParent
|
gptkb:SIRT1
|
|
gptkbp:bfsLayer
|
7
|