Extracellular signal-regulated kinase 2

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:activatedBy	phosphorylation
gptkbp:alternativeName	gptkb:ERK2 gptkb:p42MAPK MAP kinase 1
gptkbp:associatedWith	gptkb:cancer gptkb:Noonan_syndrome gptkb:cardiomyopathy
gptkbp:biologicalProcess	apoptosis cell proliferation differentiation cell cycle regulation protein serine/threonine kinase activity
gptkbp:cellularComponent	gptkb:nucleus gptkb:cytoplasm
gptkbp:discoveredBy	1991
gptkbp:EC_number	2.7.11.24
gptkbp:gene	gptkb:MAPK1
gptkbp:HGNC_ID	6871
gptkbp:inhibitedBy	dephosphorylation
gptkbp:involves	signal transduction
gptkbp:length	360
gptkbp:locatedOnChromosome	gptkb:chromosome_22q11.22
gptkbp:member	gptkb:MAP_kinase_family gptkb:ERK_subfamily
gptkbp:molecularWeight	41 kDa
gptkbp:OMIM	176948
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologInMouse	gptkb:Mapk1
gptkbp:pathway	gptkb:MAPK/ERK_pathway
gptkbp:PDB	gptkb:2ERK
gptkbp:phosphorylates	gptkb:ELK1 gptkb:RSK gptkb:c-Fos Thr185 Tyr187
gptkbp:RefSeq	NP_002736.3
gptkbp:regulates	cell survival gene expression
gptkbp:substrate	MAP2K1 (MEK1) MAP2K2 (MEK2)
gptkbp:UniProtID	gptkb:P28482
gptkbp:bfsParent	gptkb:ERK2
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Extracellular signal-regulated kinase 2