Extracellular signal-regulated kinase 2

URI: https://gptkb.org/entity/Extracellular_signal-regulated_kinase_2
GPTKB entity
Statements (46)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activatedBy phosphorylation
gptkbp:alternativeName gptkb:ERK2
gptkb:p42MAPK
MAP kinase 1
gptkbp:associatedWith gptkb:cancer
gptkb:Noonan_syndrome
cardiomyopathy
gptkbp:biologicalProcess apoptosis
cell proliferation
differentiation
cell cycle regulation
protein serine/threonine kinase activity
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
gptkbp:discoveredBy 1991
gptkbp:EC_number 2.7.11.24
gptkbp:gene gptkb:MAPK1
gptkbp:HGNC_ID 6871
https://www.w3.org/2000/01/rdf-schema#label Extracellular signal-regulated kinase 2
gptkbp:inhibitedBy dephosphorylation
gptkbp:involves signal transduction
gptkbp:length 360
gptkbp:locatedOnChromosome gptkb:chromosome_22q11.22
gptkbp:member gptkb:MAP_kinase_family
gptkb:ERK_subfamily
gptkbp:molecularWeight 41 kDa
gptkbp:OMIM 176948
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Mapk1
gptkbp:pathway gptkb:MAPK/ERK_pathway
gptkbp:PDB gptkb:2ERK
gptkbp:phosphorylates gptkb:ELK1
gptkb:RSK
gptkb:c-Fos
Thr185
Tyr187
gptkbp:RefSeq NP_002736.3
gptkbp:regulates cell survival
gene expression
gptkbp:substrate MAP2K1 (MEK1)
MAP2K2 (MEK2)
gptkbp:UniProtID gptkb:P28482
gptkbp:bfsParent gptkb:ERK2
gptkbp:bfsLayer 7