Extracellular signal-regulated kinase

URI: https://gptkb.org/entity/Extracellular_signal-regulated_kinase
GPTKB entity
Statements (44)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:ERK
gptkbp:activatedBy gptkb:MEK1
gptkb:MEK2
phosphorylation
gptkbp:alternativeName gptkb:ERK1/2
MAP kinase
gptkbp:biologicalProcess ATP binding
protein serine/threonine kinase activity
gptkbp:discoveredBy 1990s
gptkbp:encodedBy gptkb:MAPK1_gene
gptkb:MAPK3_gene
gptkbp:foundIn eukaryotes
gptkbp:function signal transduction
regulation of cell division
regulation of differentiation
regulation of proliferation
gptkbp:GO_term gptkb:GO:0004674
GO:0005524
https://www.w3.org/2000/01/rdf-schema#label Extracellular signal-regulated kinase
gptkbp:inhibitedBy phosphatases
gptkbp:involves cell cycle progression
apoptosis regulation
cellular response to growth factor stimulus
transcription regulation
cellular response to stress
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:member gptkb:mitogen-activated_protein_kinases
gptkbp:orthologInMouse gptkb:Mapk1
gptkb:Mapk3
gptkbp:part_of gptkb:MAPK/ERK_pathway
gptkbp:phosphorylates transcription factors
cytoskeletal proteins
other kinases
gptkbp:relatedTo gptkb:cancer
neurodegenerative diseases
inflammatory diseases
gptkbp:target small molecule inhibitors
therapeutic drugs
gptkbp:UniProtID gptkb:P27361
gptkb:P28482
gptkbp:bfsParent gptkb:ERK
gptkbp:bfsLayer 6