|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
gptkb:Transforming_protein_p21
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Bladder_cancer
gptkb:Costello_syndrome
Gingival fibromatosis
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:disulfideBond
|
No
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000174775
3265
|
|
gptkbp:enzymeClassification
|
gptkb:EC_3.6.5.2
|
|
gptkbp:expressedIn
|
Many tissues
|
|
gptkbp:family
|
gptkb:Ras_family
|
|
gptkbp:function
|
gptkb:Signal_transduction
guanine nucleotide exchange factor
|
|
gptkbp:gene
|
gptkb:HRAS
|
|
gptkbp:hasIsoform
|
2
|
|
gptkbp:HGNC_ID
|
5173
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P01111 (HRAS)
|
|
gptkbp:interactsWith
|
gptkb:NF1
gptkb:RASA1
gptkb:BRAF
gptkb:GRB2
gptkb:PIK3CA
gptkb:RAF1
gptkb:SOS1
|
|
gptkbp:length
|
189 amino acids
|
|
gptkbp:locatedOnChromosome
|
11
|
|
gptkbp:location
|
gptkb:11p15.5
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:G12V
gptkb:Q61L
G13R
|
|
gptkbp:OMIM
|
190020
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Hras1
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:5P21
1AA9
4Q21
|
|
gptkbp:postTranslationalModification
|
Farnesylation
Palmitoylation
|
|
gptkbp:RefSeq
|
gptkb:NP_005334.1
|
|
gptkbp:reviewedBy
|
Yes
|
|
gptkbp:sequenceStatus
|
Complete
|
|
gptkbp:signalPeptide
|
No
|
|
gptkbp:subcellularLocation
|
gptkb:Cytoplasm
gptkb:Golgi_apparatus
Plasma membrane
|
|
gptkbp:superfamily
|
Small GTPase superfamily
|
|
gptkbp:transmembraneDomains
|
No
|
|
gptkbp:UniProtID
|
gptkb:P01111
|
|
gptkbp:bfsParent
|
gptkb:Ras_protein_family
|
|
gptkbp:bfsLayer
|
7
|