|
gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:alsoKnownAs
|
cell signaling
|
|
gptkbp:canBe
|
extracellular
intracellular
|
|
gptkbp:dysfunctionLeadsTo
|
gptkb:cancer
gptkb:diabetes
autoimmune diseases
|
|
gptkbp:example
|
gptkb:TGF-beta_signaling_pathway
gptkb:MAPK/ERK_pathway
gptkb:Notch_signaling_pathway
gptkb:Wnt_signaling_pathway
gptkb:Hedgehog_signaling_pathway
gptkb:JAK-STAT_pathway
gptkb:cAMP_signaling_pathway
G protein-coupled receptor pathway
calcium signaling pathway
phosphoinositide pathway
receptor tyrosine kinase pathway
|
|
gptkbp:firstDescribed
|
20th century
|
|
gptkbp:hasNobelPrize
|
gptkb:Martin_Rodbell
gptkb:Alfred_G._Gilman
gptkb:Earl_W._Sutherland_Jr.
|
|
gptkbp:hasNobelPrizeYear
|
1971
1994
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Signal transduction
|
|
gptkbp:involves
|
phosphorylation
protein kinases
second messengers
receptors
signal amplification
|
|
gptkbp:mediatedBy
|
ions
cytokines
growth factors
hormones
neurotransmitters
ligands
|
|
gptkbp:occurredIn
|
cells
|
|
gptkbp:partOf
|
signaling molecule
cell communication
|
|
gptkbp:regulates
|
gene expression
cellular responses
|
|
gptkbp:requires
|
development
homeostasis
immune response
|
|
gptkbp:studiedIn
|
biochemistry
cell biology
molecular biology
|
|
gptkbp:bfsParent
|
gptkb:Glycoproteins
gptkb:P01138
gptkb:Class_C_(Metabotropic_glutamate/pheromone)
gptkb:P01111
gptkb:P01112
gptkb:P01116
|
|
gptkbp:bfsLayer
|
6
|