|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
leukemia
melanoma
pancreatic cancer
|
|
gptkbp:composedOf
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Weinberg
gptkb:Michael_Wigler
gptkb:Mariano_Barbacid
|
|
gptkbp:firstDescribed
|
1982
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
GTPase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ras protein family
|
|
gptkbp:involvedIn
|
regulation of cell differentiation
regulation of cell proliferation
regulation of cell survival
cell signal transduction
|
|
gptkbp:locale
|
inner surface of plasma membrane
|
|
gptkbp:memberOf
|
gptkb:small_GTPase_superfamily
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
codon 12
codon 13
codon 61
|
|
gptkbp:OMIM
|
gptkb:164790_(NRAS)
gptkb:190020_(HRAS)
gptkb:190070_(KRAS)
|
|
gptkbp:orthologIn
|
gptkb:yeast
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
mammals
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
prenylation
|
|
gptkbp:proteinFamily
|
gptkb:RAS_genes
|
|
gptkbp:regulates
|
gptkb:Ral-GDS_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:relatedTo
|
gptkb:Arf_family
gptkb:Rab_family
gptkb:Ran_family
gptkb:Rho_family
|
|
gptkbp:structure
|
contains G domain
contains switch I and II regions
|
|
gptkbp:subfamily
|
gptkb:Ras_superfamily
|
|
gptkbp:target
|
gptkb:KRAS_G12C_inhibitors
gptkb:MEK_inhibitors
farnesyltransferase inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P01111_(HRAS)
gptkb:P01111_(NRAS)
P01116 (KRAS)
|
|
gptkbp:bfsParent
|
gptkb:Ras1
|
|
gptkbp:bfsLayer
|
6
|