|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:amendedBy
|
SUMOylation of target proteins
|
|
gptkbp:binds
|
gptkb:STAT1
gptkb:STAT4
gptkb:p53
gptkb:STAT3
gptkb:NF-κB
gptkb:SMAD_proteins
gptkb:STAT5
|
|
gptkbp:discoveredBy
|
1997
|
|
gptkbp:domain
|
gptkb:PINIT_domain
gptkb:SAP_domain
gptkb:SIM_domain
gptkb:SP-RING_domain
|
|
gptkbp:expressedIn
|
humans
mammals
|
|
gptkbp:fullName
|
gptkb:Protein_Inhibitor_of_Activated_STAT_proteins
|
|
gptkbp:function
|
E3 SUMO-protein ligase activity
regulation of STAT signaling
|
|
gptkbp:gene
|
gptkb:PIAS
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIAS proteins
|
|
gptkbp:involves
|
apoptosis
cell differentiation
cell proliferation
DNA repair
oncogenesis
|
|
gptkbp:member
|
gptkb:PIAS3
gptkb:PIAS1
gptkb:PIAS2
gptkb:PIAS4
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
gptkb:Drosophila_melanogaster
right
|
|
gptkbp:regulates
|
gptkb:Wnt_signaling
gptkb:JAK-STAT_pathway
transcription
immune response
cell cycle
tumor suppression
inflammatory response
hematopoiesis
TGF-beta signaling
chromatin remodeling
antiviral response
cytokine signaling
androgen receptor signaling
estrogen receptor signaling
immune cell development
|
|
gptkbp:bfsParent
|
gptkb:JAK-STAT_signaling_pathway
gptkb:JAK-STAT_pathway
gptkb:JAK/STAT_signaling_pathway
|
|
gptkbp:bfsLayer
|
7
|