Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:Dupilumab
gptkb:dupilumab |
| gptkbp:associated_with |
Th2 cell differentiation
|
| gptkbp:combatants |
gptkb:IL-4
|
| gptkbp:established |
IL-4 binding
STA T6 Th1 response anti-IL-4 therapies |
| gptkbp:has_member |
gptkb:IL-13_Rα1
gptkb:IL-13_Rα2 gptkb:IL-4_Rα |
| gptkbp:has_role |
gptkb:asthma
atopic dermatitis chronic rhinosinusitis |
| https://www.w3.org/2000/01/rdf-schema#label |
IL-4 receptor
|
| gptkbp:is_aimed_at |
IL-4 receptor antagonists
IL-4 receptor monoclonal antibodies |
| gptkbp:is_associated_with |
gptkb:chronic_obstructive_pulmonary_disease_(COPD)
gptkb:psychologist gptkb:rheumatoid_arthritis inflammatory bowel disease (IBD) systemic lupus erythematosus (SLE) |
| gptkbp:is_found_in |
human tissues
mouse tissues |
| gptkbp:is_involved_in |
cell differentiation
cell proliferation cell signaling homeostasis immune response allergic reactions wound healing T cell activation fibrosis fungal infections immune tolerance inflammatory responses tissue repair viral infections bacterial infections cytokine production tissue remodeling antibody production metabolic regulation pathogen response parasitic infections cytokine signaling immune regulation host defense mechanisms immune cell recruitment B cell proliferation Ig E class switching inflammatory cell infiltration |
| gptkbp:is_linked_to |
autoimmune diseases
chronic inflammation |
| gptkbp:is_part_of |
IL-4 signaling pathway
Th2 signaling pathway |
| gptkbp:is_represented_in |
gptkb:T_cells
B cells mast cells eosinophils |
| gptkbp:is_studied_in |
vaccine development
cancer immunotherapy |
| gptkbp:located_in |
cell membrane
|
| gptkbp:regulates |
transcription factors
cytokines |
| gptkbp:targets |
monoclonal antibodies
|