Statements (37)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cell surface receptor |
| gptkbp:associatedWith |
gptkb:atopic_dermatitis
asthma immunodeficiency allergic diseases |
| gptkbp:binds |
gptkb:interleukin-4
gptkb:interleukin-13 |
| gptkbp:component |
immune system
|
| gptkbp:encodedBy |
gptkb:IL4R_gene
|
| gptkbp:expressedIn |
gptkb:B_cells
gptkb:T_cells macrophages endothelial cells fibroblasts epithelial cells |
| gptkbp:form |
gptkb:type_II_IL-4_receptor
gptkb:type_I_IL-4_receptor |
| gptkbp:function |
promotes Th2 cell differentiation
regulates immune response mediates IL-4 signaling |
| gptkbp:HGNC_ID |
6015
|
| https://www.w3.org/2000/01/rdf-schema#label |
IL-4 receptor
|
| gptkbp:locatedOnChromosome |
gptkb:16p12.1
|
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:OMIM |
147780
|
| gptkbp:subunit |
gptkb:IL-13Rα1
gptkb:IL-4Rα gptkb:common_gamma_chain |
| gptkbp:target |
gptkb:dupilumab
therapeutic antibodies |
| gptkbp:type |
gptkb:JAK-STAT_pathway
STAT6 activation |
| gptkbp:UniProtID |
gptkb:P24394
|
| gptkbp:bfsParent |
gptkb:IL4
gptkb:Il-4 |
| gptkbp:bfsLayer |
6
|