|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:JAK-1
gptkb:JAK1A
gptkb:JAK1B
gptkb:Janus_kinase_1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:autosomal_dominant_immunodeficiency_27A
cancers
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodedBy
|
gptkb:JAK1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000162434
|
|
gptkbp:fullName
|
gptkb:Janus_kinase_1
|
|
gptkbp:function
|
signal transduction
tyrosine kinase activity
|
|
gptkbp:GO_term
|
gptkb:GO:0004713
gptkb:GO:0007259
|
|
gptkbp:HGNC_ID
|
6190
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JAK1
|
|
gptkbp:interactsWith
|
gptkb:STAT1
gptkb:IFNGR1
gptkb:STAT3
gptkb:STAT5
gptkb:IL2RB
gptkb:IL6ST
|
|
gptkbp:involvedIn
|
gptkb:JAK-STAT_signaling_pathway
cytokine receptor signaling
|
|
gptkbp:length
|
1154 amino acids
~150 kb
|
|
gptkbp:locatedOnChromosome
|
1p31.3
|
|
gptkbp:molecularWeight
|
133 kDa
|
|
gptkbp:OMIM
|
147795
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Jak1
|
|
gptkbp:PDB
|
4EHZ
|
|
gptkbp:phosphorylates
|
gptkb:Y1034
Y1035
|
|
gptkbp:regulates
|
cell growth
immune response
hematopoiesis
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:target
|
gptkb:ruxolitinib
gptkb:tofacitinib
gptkb:baricitinib
JAK inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P23458
|
|
gptkbp:bfsParent
|
gptkb:JAK-STAT_signaling_pathway
gptkb:JAK
gptkb:STAT1
gptkb:gp130
gptkb:PTPN6
gptkb:STAT3
gptkb:JAK-STAT_pathway
gptkb:JAK/STAT_signaling_pathway
|
|
gptkbp:bfsLayer
|
7
|