|
gptkbp:instance_of
|
gptkb:Cyclin-dependent_kinase
|
|
gptkbp:associated_with
|
immune response
|
|
gptkbp:diseases
|
gptkb:disease
gptkb:rheumatoid_arthritis
autoimmune diseases
psoriasis
atopic dermatitis
|
|
gptkbp:function
|
cytokine signaling
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JAK1
|
|
gptkbp:initiated_by
|
gptkb:brigatinib
gptkb:palbociclib
gptkb:imatinib
gptkb:ruxolitinib
gptkb:venetoclax
gptkb:ibrutinib
gptkb:upadacitinib
gptkb:cobimetinib
gptkb:entrectinib
gptkb:neratinib
gptkb:osimertinib
gptkb:lorlatinib
gptkb:abemaciclib
gptkb:baricitinib
gptkb:dasatinib
gptkb:nilotinib
gptkb:sunitinib
gptkb:alectinib
gptkb:ceritinib
gptkb:crizotinib
gptkb:lapatinib
gptkb:ponatinib
gptkb:regorafenib
afatinib
vandetanib
larotrectinib
cabozantinib
tofacitinib
selinexor
lenvatinib
bosutinib
abrocitinib
dacomitinib
deucravacitinib
fedratinib
filgotinib
idasanutlin
momelotinib
pacritinib
pazopanib
peficitinib
tazemetostat
|
|
gptkbp:interacts_with
|
gptkb:IL-6_receptor
gptkb:IL-2_receptor
gptkb:IL-4_receptor
IL-10 receptor
EPO receptor
GM-CSF receptor
IFN-γ receptor
IL-12 receptor
TGF-β receptor
|
|
gptkbp:involved_in
|
apoptosis
cell differentiation
cell proliferation
signal transduction
immune regulation
|
|
gptkbp:is_expressed_in
|
gptkb:T_cells
|
|
gptkbp:located_in
|
human body
|
|
gptkbp:promoter
|
JAK1 gene
|
|
gptkbp:related_to
|
JAK-STAT signaling pathway
|
|
gptkbp:role
|
hematopoiesis
|
|
gptkbp:bfsParent
|
gptkb:STAT3
gptkb:Filgotinib
|
|
gptkbp:bfsLayer
|
6
|