|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:JTK10
gptkb:Janus_kinase_2,_non-receptor_tyrosine_kinase
|
|
gptkbp:discoveredBy
|
Darnell JE Jr. et al.
|
|
gptkbp:domain
|
kinase domain
SH2 domain
FERM domain
pseudokinase domain
|
|
gptkbp:encodedBy
|
gptkb:JAK2_gene
|
|
gptkbp:Entrez_Gene_ID
|
3717
|
|
gptkbp:enzymeCommissionNumber
|
2.7.10.2
|
|
gptkbp:expressedIn
|
hematopoietic cells
|
|
gptkbp:fullName
|
gptkb:Janus_kinase_2
|
|
gptkbp:function
|
signal transduction
tyrosine kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6192
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JAK2
|
|
gptkbp:interactsWith
|
gptkb:EPOR
gptkb:GHR
gptkb:IFNGR1
gptkb:PRLR
gptkb:STAT5
|
|
gptkbp:involvedIn
|
gptkb:JAK-STAT_signaling_pathway
|
|
gptkbp:length
|
1132
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9
|
|
gptkbp:memberOf
|
gptkb:Janus_kinase_family
|
|
gptkbp:molecularWeight
|
131 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:V617F
gptkb:polycythemia_vera
essential thrombocythemia
primary myelofibrosis
|
|
gptkbp:OMIM
|
147796
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:4BBE
|
|
gptkbp:phosphorylates
|
gptkb:STAT_proteins
Y1007
Y1008
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
immune response
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:target
|
gptkb:fedratinib
gptkb:ruxolitinib
gptkb:momelotinib
gptkb:pacritinib
|
|
gptkbp:UniProtID
|
O60674
|
|
gptkbp:bfsParent
|
gptkb:JAK2_mutation
gptkb:myelofibrosis
|
|
gptkbp:bfsLayer
|
6
|