|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:atopic_dermatitis
asthma
inflammatory bowel disease
allergic diseases
|
|
gptkbp:discoveredBy
|
gptkb:Darnell_lab
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:domain
|
SH2 domain
DNA-binding domain
|
|
gptkbp:encodedBy
|
gptkb:STAT6_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000166888
6778
|
|
gptkbp:fullName
|
gptkb:Signal_transducer_and_activator_of_transcription_6
|
|
gptkbp:function
|
transcription factor
mediates IL-4 and IL-13 signaling
|
|
gptkbp:gene
|
gptkb:STAT6
|
|
gptkbp:HGNC_ID
|
11366
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
STAT6
|
|
gptkbp:inhibitedBy
|
gptkb:SOCS_proteins
|
|
gptkbp:interactsWith
|
gptkb:CBP/p300
gptkb:IL-4_receptor_alpha
gptkb:JAK1
gptkb:CREB-binding_protein
gptkb:JAK3
gptkb:NCoA-1
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
|
|
gptkbp:molecularWeight
|
94 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Stat6
gptkb:rat_Stat6
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:1BG1
|
|
gptkbp:phosphorylates
|
activated by JAK kinases
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:proteinFamily
|
gptkb:STAT_protein_family
|
|
gptkbp:regulates
|
IgE production
GATA3 expression
IL-4 responsive genes
|
|
gptkbp:role
|
regulation of immune response
IgE class switching
Th2 cell differentiation
|
|
gptkbp:subcellularLocation
|
cytoplasm before activation
nucleus after activation
|
|
gptkbp:UniProtID
|
gptkb:P42226
|
|
gptkbp:bfsParent
|
gptkb:JAK-STAT_signaling_pathway
gptkb:STAT_pathway
gptkb:STATs
gptkb:STAT_proteins
gptkb:IL4_gene
gptkb:NAB2
gptkb:T_helper_2_cells
gptkb:Th2_cells
gptkb:JAK-STAT_pathway
gptkb:JAK/STAT_signaling_pathway
|
|
gptkbp:bfsLayer
|
7
|