|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:SSI_proteins
gptkb:STAT-induced_STAT_inhibitor_proteins
|
|
gptkbp:discoveredBy
|
gptkb:Douglas_J._Hilton
|
|
gptkbp:domain
|
gptkb:SOCS_box
SH2 domain
|
|
gptkbp:expressedIn
|
immune cells
|
|
gptkbp:firstDescribed
|
1997
|
|
gptkbp:fullName
|
gptkb:Suppressor_of_Cytokine_Signaling_proteins
|
|
gptkbp:function
|
negative regulation of cytokine signaling
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SOCS proteins
|
|
gptkbp:inhibitedBy
|
gptkb:STAT_transcription_factors
gptkb:JAK_kinases
|
|
gptkbp:involves
|
gptkb:cancer
autoimmune diseases
inflammatory diseases
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:member
|
gptkb:SOCS1
gptkb:SOCS2
gptkb:SOCS3
gptkb:SOCS4
gptkb:SOCS5
gptkb:SOCS6
gptkb:SOCS7
gptkb:CIS_(Cytokine_Inducible_SH2-containing_protein)
|
|
gptkbp:orthologIn
|
gptkb:fish
birds
mammals
|
|
gptkbp:proteinFamily
|
gptkb:SOCS_gene_family
|
|
gptkbp:regulates
|
gptkb:JAK-STAT_signaling_pathway
cytokine receptor signaling
|
|
gptkbp:bfsParent
|
gptkb:Insulin_receptor
|
|
gptkbp:bfsLayer
|
6
|