platelet-derived growth factor receptor beta

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:receptor_tyrosine_kinase gptkb:protein
gptkbp:alternativeName	gptkb:PDGFRB gptkb:CD140b gptkb:PDGFR-beta
gptkbp:associatedWith	gptkb:idiopathic_basal_ganglia_calcification gptkb:chronic_myelomonocytic_leukemia gptkb:infantile_myofibromatosis
gptkbp:biologicalProcess	cell proliferation embryonic development signal transduction wound healing cell migration ATP binding protein kinase activity
gptkbp:cellularComponent	gptkb:plasma_membrane
gptkbp:dimerization	homodimer heterodimer with PDGFRA
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000113721
gptkbp:expressedIn	pericytes vascular smooth muscle cells
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	cell differentiation angiogenesis cell growth regulation
gptkbp:gene	gptkb:PDGFRB
gptkbp:HGNC_ID	8804
https://www.w3.org/2000/01/rdf-schema#label	platelet-derived growth factor receptor beta
gptkbp:ligand	gptkb:platelet-derived_growth_factor
gptkbp:locatedOnChromosome	5q32
gptkbp:location	gptkb:cell_membrane
gptkbp:mutationAssociatedWith	oncogenic transformation vascular disorders
gptkbp:OMIM	173410
gptkbp:PDB	3MJG
gptkbp:phosphorylates	tyrosine residues
gptkbp:postTranslationalModification	phosphorylation glycosylation
gptkbp:reviewedBy	gptkb:GeneCards gptkb:UniProt
gptkbp:signal_transduction_pathway	gptkb:MAPK_pathway gptkb:PI3K-Akt_pathway gptkb:JAK-STAT_pathway
gptkbp:targetOfDrug	gptkb:sorafenib gptkb:imatinib gptkb:sunitinib
gptkbp:UniProtID	gptkb:P09619
gptkbp:bfsParent	gptkb:PDGFRB
gptkbp:bfsLayer	6