|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
cytokine receptors
|
|
gptkbp:alsoKnownAs
|
gptkb:JAKs
|
|
gptkbp:associatedWith
|
gptkb:JAK-STAT_signaling_pathway
|
|
gptkbp:biologicalProcess
|
phosphorylation of tyrosine residues
|
|
gptkbp:discoveredBy
|
gptkb:Darnell,_James_E._Jr.
|
|
gptkbp:EC_number
|
2.7.10.2
|
|
gptkbp:foundIn
|
vertebrates
|
|
gptkbp:function
|
tyrosine kinase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Janus kinases
|
|
gptkbp:inhibitedBy
|
gptkb:fedratinib
gptkb:ruxolitinib
gptkb:tofacitinib
gptkb:upadacitinib
gptkb:momelotinib
gptkb:pacritinib
gptkb:baricitinib
gptkb:PF-06651600
gptkb:PF-04965842
gptkb:abrocitinib
gptkb:decernotinib
gptkb:delgocitinib
gptkb:filgotinib
gptkb:gandotinib
gptkb:itacitinib
gptkb:lestaurtinib
gptkb:peficitinib
gptkb:rebastinib
gptkb:solcitinib
gptkb:tideglusib
|
|
gptkbp:involvedIn
|
cytokine receptor signaling
|
|
gptkbp:involves
|
gptkb:cancer
autoimmune diseases
myeloproliferative disorders
|
|
gptkbp:locale
|
gptkb:cytoplasm
|
|
gptkbp:member
|
gptkb:JAK2
gptkb:JAK1
gptkb:TYK2
gptkb:JAK3
|
|
gptkbp:mutationAssociatedWith
|
gptkb:polycythemia_vera
essential thrombocythemia
primary myelofibrosis
|
|
gptkbp:namedAfter
|
Roman god Janus
|
|
gptkbp:phosphorylates
|
gptkb:STAT_proteins
|
|
gptkbp:proteinFamily
|
gptkb:protein_tyrosine_kinases
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:structure
|
contains kinase domain
contains pseudokinase domain
contains FERM domain
contains SH2 domain
|
|
gptkbp:target
|
JAK inhibitors
|
|
gptkbp:bfsParent
|
gptkb:JAK-STAT_signaling_pathway
gptkb:JAK-STAT_pathway
|
|
gptkbp:bfsLayer
|
7
|