|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:systemic_lupus_erythematosus
autoimmune diseases
psoriasis
immunodeficiency
|
|
gptkbp:encodes
|
gptkb:tyrosine-protein_kinase_TYK2
|
|
gptkbp:Entrez_Gene_ID
|
7297
ENSG00000105397
|
|
gptkbp:expressedIn
|
immune cells
|
|
gptkbp:fullName
|
gptkb:Tyrosine_kinase_2
|
|
gptkbp:function
|
mediates cytokine signaling
|
|
gptkbp:HGNC_ID
|
HGNC:12440
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TYK2
|
|
gptkbp:interactsWith
|
gptkb:STAT1
gptkb:JAK1
gptkb:STAT4
gptkb:STAT3
gptkb:IFNAR1
gptkb:IL10RB
|
|
gptkbp:involvedIn
|
gptkb:JAK-STAT_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.2
gptkb:chromosome_19
|
|
gptkbp:memberOf
|
gptkb:Janus_kinase_family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:immunodeficiency_35
|
|
gptkbp:OMIM
|
176941
|
|
gptkbp:orthologInMouse
|
gptkb:Tyk2
|
|
gptkbp:PDB
|
4OLI
|
|
gptkbp:target
|
gptkb:BMS-986165
gptkb:deucravacitinib
|
|
gptkbp:UniProtID
|
P29597
|
|
gptkbp:bfsParent
|
gptkb:JAK-STAT_signaling_pathway
gptkb:JAK
gptkb:JAK-STAT_pathway
gptkb:JAK/STAT_signaling_pathway
|
|
gptkbp:bfsLayer
|
7
|