gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
gptkbp:alternativeName
|
gptkb:JAK-3
gptkb:JAK3_HUMAN
gptkb:JAKL
gptkb:Janus_kinase_family_member_3
|
gptkbp:associatedWith
|
gptkb:severe_combined_immunodeficiency_(SCID)
|
gptkbp:biologicalProcess
|
immune response
protein tyrosine kinase activity
|
gptkbp:discoveredBy
|
gptkb:O'Shea_et_al.
|
gptkbp:discoveredIn
|
1994
|
gptkbp:domain
|
SH2 domain
protein kinase domain
FERM domain
JH1 domain
JH2 domain
|
gptkbp:encodedBy
|
gptkb:JAK3_gene
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000105639
3718
|
gptkbp:expressedIn
|
hematopoietic cells
|
gptkbp:fullName
|
gptkb:Janus_kinase_3
|
gptkbp:function
|
non-receptor tyrosine kinase
|
gptkbp:HGNC_ID
|
6193
|
https://www.w3.org/2000/01/rdf-schema#label
|
JAK3
|
gptkbp:inhibitedBy
|
gptkb:CP-690550
gptkb:PF-06651600
PRN371
|
gptkbp:interactsWith
|
gptkb:common_gamma_chain_(IL2RG)
|
gptkbp:involvedIn
|
cytokine receptor signaling
|
gptkbp:length
|
1124
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
|
gptkbp:memberOf
|
gptkb:Janus_kinase_family
|
gptkbp:molecularWeight
|
125 kDa
|
gptkbp:mutationAssociatedWith
|
gptkb:autosomal_recessive_SCID
|
gptkbp:OMIM
|
600173
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
gptkbp:orthologInMouse
|
gptkb:Jak3
|
gptkbp:PDB
|
gptkb:4Z16
|
gptkbp:phosphorylates
|
Y980
Y981
|
gptkbp:RefSeq
|
NM_000215
|
gptkbp:regulates
|
gptkb:STAT1
gptkb:STAT3
gptkb:STAT5
|
gptkbp:target
|
gptkb:ruxolitinib
gptkb:tofacitinib
gptkb:upadacitinib
|
gptkbp:UniProtID
|
gptkb:P52333
|
gptkbp:bfsParent
|
gptkb:immunodeficiency
|
gptkbp:bfsLayer
|
6
|