|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:GSK3B
gptkb:GSK-3_beta
gptkb:glycogen_synthase_kinase-3_beta
GSK3-beta
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes_mellitus
bipolar disorder
|
|
gptkbp:chromosomeArm
|
3q13.33
|
|
gptkbp:discoveredBy
|
Woodgett JR
Doble BW
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodes
|
glycogen synthase kinase 3 beta protein
|
|
gptkbp:Entrez_Gene_ID
|
2932
ENSG00000082701
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart
liver
pancreas
|
|
gptkbp:fullName
|
glycogen synthase kinase 3 beta
|
|
gptkbp:function
|
serine/threonine protein kinase
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
4617
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GSK3B gene
|
|
gptkbp:inhibitedBy
|
gptkb:SB-216763
gptkb:insulin
gptkb:CHIR99021
lithium
ATP-competitive inhibitors
|
|
gptkbp:involvedIn
|
gptkb:Wnt_signaling_pathway
apoptosis
cell cycle regulation
neurogenesis
glycogen metabolism
insulin signaling pathway
|
|
gptkbp:length
|
12,000 bases (approximate)
|
|
gptkbp:locatedOnChromosome
|
3
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
mitochondrion
|
|
gptkbp:mRNA_RefSeq
|
NM_002093
|
|
gptkbp:numberOfExons
|
12
|
|
gptkbp:OMIM
|
605004
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
gptkb:Notch_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Hedgehog_signaling_pathway
|
|
gptkbp:phosphorylates
|
gptkb:cyclin_D1
gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:CREB
gptkb:c-Jun
gptkb:beta-catenin
NFATC4
|
|
gptkbp:product
|
GSK3B protein
|
|
gptkbp:protein_RefSeq
|
NP_002084
|
|
gptkbp:regulates
|
gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:beta-catenin
transcription factors
|
|
gptkbp:UniProtID
|
gptkb:P49841
|
|
gptkbp:bfsParent
|
gptkb:GSK3B
|
|
gptkbp:bfsLayer
|
6
|