glycogen synthase kinase-3 beta

URI: https://gptkb.org/entity/glycogen_synthase_kinase-3_beta
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:GSK3B
gptkb:GSK-3_beta
glycogen synthase kinase 3 beta
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes_mellitus
bipolar disorder
gptkbp:discoveredBy Woodgett JR
gptkbp:discoveredIn 1990
gptkbp:enzymeCommissionNumber EC 2.7.11.26
gptkbp:expressedIn gptkb:skeletal_muscle
brain
heart
liver
pancreas
gptkbp:function serine/threonine protein kinase
phosphorylation of glycogen synthase
gptkbp:gene gptkb:GSK3B
https://www.w3.org/2000/01/rdf-schema#label glycogen synthase kinase-3 beta
gptkbp:inhibitedBy gptkb:SB-216763
gptkb:CHIR99021
lithium
gptkbp:involves gptkb:Wnt_signaling_pathway
cell proliferation
insulin signaling pathway
cellular apoptosis
gptkbp:locatedOnChromosome 3q13.33
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight 47 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Gsk3b
gptkbp:PDB gptkb:1Q4L
gptkbp:phosphorylates Ser9
Tyr216
gptkbp:postTranslationalModification phosphorylation
ubiquitination
acetylation
gptkbp:proteinFamily serine/threonine protein kinase family
glycogen synthase kinase family
gptkbp:regulates activated by phosphorylation at Tyr216
inhibited by phosphorylation at Ser9
gptkbp:substrate gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:beta-catenin
gptkbp:UniProtID gptkb:P49841
gptkbp:bfsParent gptkb:CHEMBL1201197
gptkbp:bfsLayer 6