|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:FK506-binding_protein_12-rapamycin-associated_protein_1
gptkb:FRAP
gptkb:Mechanistic_target_of_rapamycin
|
|
gptkbp:associatedWith
|
gptkb:tuberous_sclerosis
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000198793
2475
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:function
|
regulation of cell proliferation
regulation of cell survival
kinase activity
regulation of cell growth
regulation of cell motility
regulation of protein synthesis
|
|
gptkbp:gene
|
gptkb:MTOR
|
|
gptkbp:HGNC_ID
|
3942
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P49841
|
|
gptkbp:inhibitedBy
|
gptkb:everolimus
gptkb:rapamycin
gptkb:temsirolimus
gptkb:torin1
|
|
gptkbp:interactsWith
|
gptkb:AKT1
gptkb:DEPTOR
gptkb:MLST8
gptkb:TSC1
gptkb:TSC2
gptkb:RPTOR
|
|
gptkbp:KEGGID
|
hsa:2475
|
|
gptkbp:length
|
2549 amino acids
|
|
gptkbp:locatedOnChromosome
|
1p36.2-p34
|
|
gptkbp:molecularWeight
|
289,347 Da
|
|
gptkbp:OMIM
|
601231
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:phosphorylates
|
Ser2448
Ser2481
|
|
gptkbp:protein_name
|
gptkb:Serine/threonine-protein_kinase_mTOR
|
|
gptkbp:proteinFamily
|
gptkb:PF00069
|
|
gptkbp:Reactome
|
R-HSA-165159
|
|
gptkbp:RefSeq
|
NP_004949.1
|
|
gptkbp:sequenceStatus
|
reviewed
|
|
gptkbp:structure
|
has solved 3D structure
|
|
gptkbp:subcellularLocation
|
gptkb:endoplasmic_reticulum
gptkb:lysosome
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P49841
|
|
gptkbp:bfsParent
|
gptkb:GSK3B
gptkb:GSK3
|
|
gptkbp:bfsLayer
|
6
|