|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:CTNNB1
gptkb:Catenin_beta-1
tumor suppressor
|
|
gptkbp:degradedBy
|
gptkb:proteasome
|
|
gptkbp:discoveredBy
|
Rolf Kemler
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
gptkb:CTNNB1_gene
|
|
gptkbp:Entrez_Gene_ID
|
1499
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:Wnt_signaling_pathway
cell adhesion
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
beta-catenin
|
|
gptkbp:interactsWith
|
gptkb:APC_protein
gptkb:TCF/LEF_transcription_factors
gptkb:cadherins
|
|
gptkbp:involvedIn
|
cell proliferation
stem cell renewal
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~92 kDa
|
|
gptkbp:orthologIn
|
Drosophila melanogaster (Armadillo protein)
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:GSK-3β
|
|
gptkbp:role
|
gptkb:medulloblastoma
colorectal cancer
embryogenesis
hepatocellular carcinoma
axis formation
|
|
gptkbp:structure
|
contains armadillo repeats
|
|
gptkbp:UniProtID
|
gptkb:P35222
|
|
gptkbp:bfsParent
|
gptkb:CTNNB1
|
|
gptkbp:bfsLayer
|
5
|