|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abnormalAccumulation
|
leads to neurodegeneration
|
|
gptkbp:abnormalForm
|
neurofibrillary tangles
|
|
gptkbp:aggregatesFrom
|
gptkb:paired_helical_filaments
|
|
gptkbp:alternativeSplicing
|
6 isoforms in adult human brain
|
|
gptkbp:associatedWith
|
gptkb:Pick's_disease
gptkb:Alzheimer's_disease
gptkb:corticobasal_degeneration
gptkb:progressive_supranuclear_palsy
frontotemporal dementia
|
|
gptkbp:cleavage
|
gptkb:calpain
caspase
|
|
gptkbp:degradedBy
|
autophagy
ubiquitin-proteasome system
|
|
gptkbp:discoveredBy
|
gptkb:Marc_Kirschner
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:encodedBy
|
gptkb:MAPT_gene
|
|
gptkbp:foundIn
|
gptkb:human
|
|
gptkbp:function
|
stabilizes microtubules
|
|
gptkbp:hasBiomarker
|
gptkb:Alzheimer's_disease
gptkb:trauma
|
|
gptkbp:interactsWith
|
gptkb:kinases
gptkb:protein_phosphatase_2A
heat shock proteins
microtubules
|
|
gptkbp:involvedIn
|
gptkb:synaptic_plasticity
gptkb:axonal_transport
cell signaling
microtubule assembly
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17q21
|
|
gptkbp:location
|
gptkb:axon
gptkb:neurons
|
|
gptkbp:molecularWeight
|
45-65 kDa
|
|
gptkbp:mutationAssociatedWith
|
MAPT gene causes frontotemporal dementia
|
|
gptkbp:pathologicalForm
|
gptkb:hyperphosphorylated_tau
oligomeric tau
truncated tau
|
|
gptkbp:phosphorylates
|
gptkb:tyrosine
serine
threonine
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:presentIn
|
cerebrospinal fluid
|
|
gptkbp:role
|
gptkb:tauopathies
|
|
gptkbp:structure
|
contains microtubule-binding repeats
|
|
gptkbp:studiedIn
|
gptkb:transgenic_mouse_models
|
|
gptkbp:target
|
therapeutic antibodies
small molecule inhibitors
|
|
gptkbp:UniProtID
|
P10636
|
|
gptkbp:bfsParent
|
gptkb:GSK3
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
tau protein
|