tau protein

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abnormalAccumulation leads to neurodegeneration
gptkbp:abnormalForm neurofibrillary tangles
gptkbp:aggregatesFrom gptkb:paired_helical_filaments
gptkbp:alternativeSplicing 6 isoforms in adult human brain
gptkbp:associatedWith gptkb:Pick's_disease
gptkb:Alzheimer's_disease
gptkb:corticobasal_degeneration
gptkb:progressive_supranuclear_palsy
frontotemporal dementia
gptkbp:cleavage gptkb:calpain
caspase
gptkbp:degradedBy autophagy
ubiquitin-proteasome system
gptkbp:discoveredBy gptkb:Marc_Kirschner
gptkbp:discoveredIn 1975
gptkbp:encodedBy gptkb:MAPT_gene
gptkbp:foundIn gptkb:human
gptkbp:function stabilizes microtubules
gptkbp:hasBiomarker gptkb:Alzheimer's_disease
gptkb:trauma
https://www.w3.org/2000/01/rdf-schema#label tau protein
gptkbp:interactsWith gptkb:kinases
gptkb:protein_phosphatase_2A
heat shock proteins
microtubules
gptkbp:involvedIn gptkb:synaptic_plasticity
gptkb:axonal_transport
cell signaling
microtubule assembly
gptkbp:locatedOnChromosome gptkb:chromosome_17q21
gptkbp:location neurons
axon
gptkbp:molecularWeight 45-65 kDa
gptkbp:mutationAssociatedWith MAPT gene causes frontotemporal dementia
gptkbp:pathologicalForm gptkb:hyperphosphorylated_tau
oligomeric tau
truncated tau
gptkbp:phosphorylates gptkb:tyrosine
serine
threonine
gptkbp:postTranslationalModification phosphorylation
gptkbp:presentIn cerebrospinal fluid
gptkbp:role gptkb:tauopathies
gptkbp:structure contains microtubule-binding repeats
gptkbp:studiedIn gptkb:transgenic_mouse_models
gptkbp:target therapeutic antibodies
small molecule inhibitors
gptkbp:UniProtID P10636
gptkbp:bfsParent gptkb:GSK3B
gptkb:GSK3
gptkbp:bfsLayer 6