FK506-binding protein 12-rapamycin-associated protein 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:mTOR gptkb:FRAP1
gptkbp:associatedWith	gptkb:tuberous_sclerosis gptkb:cancer gptkb:type_2_diabetes neurodegenerative diseases
gptkbp:component	gptkb:mTORC2_complex mTORC1 complex
gptkbp:encodedBy	gptkb:MTOR_gene
gptkbp:enzymeCommissionNumber	2.7.11.1
gptkbp:function	regulation of cell proliferation regulation of cell survival regulation of transcription regulation of cell growth regulation of cell motility regulation of protein synthesis serine/threonine-protein kinase
gptkbp:gene	gptkb:MTOR
https://www.w3.org/2000/01/rdf-schema#label	FK506-binding protein 12-rapamycin-associated protein 1
gptkbp:inhibitedBy	gptkb:rapamycin FKBP12-rapamycin complex
gptkbp:interactsWith	gptkb:DEPTOR gptkb:MLST8 gptkb:RICTOR gptkb:TSC1 gptkb:TSC2 gptkb:FKBP12 gptkb:RPTOR
gptkbp:locatedOnChromosome	gptkb:chromosome_1p36.2
gptkbp:molecularWeight	~289 kDa
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Saccharomyces_cerevisiae gptkb:Drosophila_melanogaster gptkb:Rattus_norvegicus
gptkbp:pathway	gptkb:mTOR_signaling_pathway gptkb:PI3K-Akt_signaling_pathway insulin signaling pathway
gptkbp:phosphorylates	gptkb:4EBP1 gptkb:AKT1 gptkb:S6K1 gptkb:ULK1 gptkb:TFEB
gptkbp:subcellularLocation	gptkb:endoplasmic_reticulum gptkb:lysosome gptkb:nucleus gptkb:cytoplasm
gptkbp:UniProtID	gptkb:P42345
gptkbp:bfsParent	gptkb:P49841 gptkb:mTOR_(mechanistic_target_of_rapamycin) gptkb:P49815
gptkbp:bfsLayer	7