|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:mammalian_target_of_rapamycin
gptkb:mechanistic_target_of_rapamycin
gptkb:mTOR
|
|
gptkbp:associatedWith
|
gptkb:tuberous_sclerosis
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
|
|
gptkbp:component
|
gptkb:mTORC1
gptkb:mTORC2
|
|
gptkbp:domain
|
gptkb:FATC_domain
gptkb:FAT_domain
gptkb:HEAT_repeats
kinase domain
FRB domain
|
|
gptkbp:encodes
|
gptkb:mTOR
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000198793
2475
|
|
gptkbp:fullName
|
gptkb:FK506_binding_protein_12-rapamycin_associated_protein_1
|
|
gptkbp:function
|
serine/threonine protein kinase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FRAP1
|
|
gptkbp:inhibitedBy
|
gptkb:rapamycin
FKBP12-rapamycin complex
|
|
gptkbp:involvedIn
|
cell proliferation
cell survival
transcription
cell growth
protein synthesis
cell motility
|
|
gptkbp:locatedOnChromosome
|
chromosome 1p36.2-p34
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
gptkb:lysosome
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:memberOf
|
PI3K-related kinase family
|
|
gptkbp:OMIM
|
601231
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Mtor
|
|
gptkbp:phosphorylates
|
gptkb:4EBP1
gptkb:S6K1
gptkb:ULK1
gptkb:AKT
|
|
gptkbp:regulates
|
stress
growth factors
nutrients
cellular energy
|
|
gptkbp:UniProtID
|
gptkb:P42345
|
|
gptkbp:bfsParent
|
gptkb:MTOR
gptkb:mechanistic_target_of_rapamycin
gptkb:mTOR_(mechanistic_target_of_rapamycin)
|
|
gptkbp:bfsLayer
|
7
|