|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:insulin
growth factors
amino acids
nutrients
|
|
gptkbp:alsoKnownAs
|
gptkb:mammalian_target_of_rapamycin
gptkb:FK506_binding_protein_12-rapamycin_associated_protein_1
gptkb:FRAP1
|
|
gptkbp:associatedWith
|
gptkb:tuberous_sclerosis
gptkb:cancer
gptkb:diabetes
epilepsy
neurodegenerative diseases
|
|
gptkbp:discoveredBy
|
gptkb:David_Sabatini
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:mTOR_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000198793
2475
|
|
gptkbp:expressedIn
|
many human tissues
|
|
gptkbp:formsComplexWith
|
gptkb:mTORC1
gptkb:mTORC2
|
|
gptkbp:fullName
|
gptkb:mechanistic_target_of_rapamycin
|
|
gptkbp:function
|
serine/threonine kinase
regulates protein synthesis
regulates cell proliferation
regulates cell survival
regulates autophagy
regulates cell growth
regulates cell motility
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
3942
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MTOR
|
|
gptkbp:inhibitedBy
|
gptkb:everolimus
gptkb:rapamycin
gptkb:sirolimus
gptkb:temsirolimus
|
|
gptkbp:locatedIn
|
gptkb:chromosome_1p36.2
|
|
gptkbp:memberOf
|
PI3K-related kinase family
|
|
gptkbp:OMIM
|
601231
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
yeast (TOR1, TOR2)
|
|
gptkbp:PDB
|
4JSV
|
|
gptkbp:phosphorylates
|
gptkb:4EBP1
gptkb:S6K1
gptkb:ULK1
gptkb:AKT
gptkb:TFEB
|
|
gptkbp:regulates
|
angiogenesis
lipid synthesis
ribosome biogenesis
translation initiation
mitochondrial metabolism
|
|
gptkbp:UniProtID
|
gptkb:P42345
|
|
gptkbp:bfsParent
|
gptkb:mTOR
gptkb:mTORC2
|
|
gptkbp:bfsLayer
|
6
|