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gptkbp:instanceOf
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gptkb:gene
|
|
gptkbp:alternativeName
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gptkb:FK506_binding_protein_12-rapamycin_associated_protein_1
gptkb:FRAP1
|
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gptkbp:associatedWith
|
gptkb:tuberous_sclerosis_complex
gptkb:cancer
epilepsy
Smith-Kingsmore syndrome
focal cortical dysplasia
|
|
gptkbp:component
|
gptkb:mTORC2_complex
mTORC1 complex
|
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gptkbp:discoveredBy
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gptkb:David_M._Sabatini
|
|
gptkbp:discoveredIn
|
1994
|
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gptkbp:encodes
|
gptkb:mTOR_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000198793
2475
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
many tissues
|
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gptkbp:fullName
|
mechanistic target of rapamycin gene
|
|
gptkbp:function
|
regulation of cell proliferation
regulation of cell survival
regulation of autophagy
regulation of cell growth
regulation of protein synthesis
|
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gptkbp:GO_term
|
GO:0006468 (protein phosphorylation)
GO:0006914 (autophagy)
GO:0008284 (positive regulation of cell proliferation)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MTOR gene
|
|
gptkbp:inhibitedBy
|
gptkb:everolimus
gptkb:rapamycin
gptkb:temsirolimus
|
|
gptkbp:interactsWith
|
gptkb:4EBP1
gptkb:AKT1
gptkb:DEPTOR
gptkb:MLST8
gptkb:PRAS40
gptkb:RICTOR
gptkb:S6K1
gptkb:TSC1
gptkb:TSC2
gptkb:AMPK
gptkb:RPTOR
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.2
chromosome 1
|
|
gptkbp:mutationAssociatedWith
|
can lead to abnormal cell growth
can cause hyperactivation of mTOR pathway
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologInMouse
|
Mtor
|
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
AMPK signaling pathway
|
|
gptkbp:product
|
serine/threonine-protein kinase mTOR
|
|
gptkbp:proteinFamily
|
PIKK family
|
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gptkbp:regulates
|
angiogenesis
lipid synthesis
glucose metabolism
immune response
cell metabolism
cell motility
ribosome biogenesis
|
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gptkbp:UniProtID
|
gptkb:P42345
|
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gptkbp:bfsParent
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gptkb:mammalian_target_of_rapamycin
gptkb:mechanistic_target_of_rapamycin
gptkb:mTOR_(mechanistic_target_of_rapamycin)
gptkb:mammalian_target_of_rapamycin_(mTOR)
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gptkbp:bfsLayer
|
7
|