|
gptkbp:instanceOf
|
gptkb:protein
immunophilin
|
|
gptkbp:alternativeName
|
12 kDa FK506-binding protein
FK506-binding protein 1A
PPIase
|
|
gptkbp:binds
|
FK506 (tacrolimus)
rapamycin (sirolimus)
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:domain
|
FKBP_C domain
|
|
gptkbp:encodedBy
|
FKBP1A gene
|
|
gptkbp:Entrez_Gene_ID
|
2280
|
|
gptkbp:enzymeCommissionNumber
|
EC 5.2.1.8
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:family
|
FKBP-type peptidyl-prolyl cis-trans isomerase family
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
peptidyl-prolyl cis-trans isomerase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FKBP12
|
|
gptkbp:inhibitedBy
|
calcineurin (when complexed with FK506)
mTOR (when complexed with rapamycin)
|
|
gptkbp:inhibitorOf
|
calcineurin (when complexed with FK506)
mTOR (when complexed with rapamycin)
|
|
gptkbp:interactsWith
|
gptkb:ryanodine_receptor
gptkb:TGF-beta_receptor_type_I
|
|
gptkbp:length
|
108
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.32
|
|
gptkbp:molecularWeight
|
12 kDa
|
|
gptkbp:OMIM
|
186945
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:FKBP38
gptkb:FKBP51
gptkb:FKBP52
gptkb:Rattus_norvegicus
gptkb:FKBP12.6
FKBP8
FKBP10
FKBP11
FKBP13
FKBP14
FKBP25
FKBP65
FKBP9
|
|
gptkbp:PDB
|
1FKF
|
|
gptkbp:role
|
immunosuppression
protein folding
|
|
gptkbp:structure
|
mainly alpha-helical
|
|
gptkbp:target
|
immunosuppressive drugs
|
|
gptkbp:UniProtID
|
P62942
|
|
gptkbp:bfsParent
|
gptkb:rapamycin
|
|
gptkbp:bfsLayer
|
6
|