TFEB

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:activatedBy starvation
lysosomal stress
gptkbp:alternativeName bHLHe35
transcription factor EB
gptkbp:associatedWith gptkb:cancer
neurodegenerative diseases
renal cell carcinoma
gptkbp:binds CLEAR element
gptkbp:discoveredBy Sardiello et al.
gptkbp:discoveredIn 2009
gptkbp:encodedBy TFEB gene
gptkbp:Entrez_Gene_ID 7942
ENSG00000175899
gptkbp:fullName Transcription Factor EB
gptkbp:function transcription factor
gptkbp:HGNC_ID HGNC:11755
https://www.w3.org/2000/01/rdf-schema#label TFEB
gptkbp:inhibitedBy nutrient abundance
gptkbp:interactsWith gptkb:14-3-3_proteins
gptkb:Rag_GTPases
gptkb:mTORC1
gptkbp:locatedOnChromosome gptkb:6p21.1
gptkbp:memberOf MiT/TFE family
gptkbp:mutationAssociatedWith gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
melanoma
renal cell carcinoma
lysosomal storage disorders
gptkbp:orthologInMouse Tfeb
gptkbp:phosphorylates gptkb:mTORC1
Serine 211
gptkbp:regulates apoptosis
cell differentiation
cell proliferation
cell survival
lipid metabolism
inflammation
immune response
cellular metabolism
autophagy
mitochondrial biogenesis
stress response
TFEB target genes
cellular clearance
lysosomal biogenesis
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:UniProtID P19484
gptkbp:bfsParent gptkb:MTOR
gptkb:mammalian_target_of_rapamycin
gptkbp:bfsLayer 7