|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
starvation
lysosomal stress
|
|
gptkbp:alternativeName
|
bHLHe35
transcription factor EB
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:renal_cell_carcinoma
neurodegenerative diseases
|
|
gptkbp:binds
|
CLEAR element
|
|
gptkbp:discoveredBy
|
Sardiello et al.
|
|
gptkbp:discoveredIn
|
2009
|
|
gptkbp:encodedBy
|
TFEB gene
|
|
gptkbp:Entrez_Gene_ID
|
7942
ENSG00000175899
|
|
gptkbp:fullName
|
Transcription Factor EB
|
|
gptkbp:function
|
gptkb:transcription_factor
|
|
gptkbp:HGNC_ID
|
HGNC:11755
|
|
gptkbp:inhibitedBy
|
nutrient abundance
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:Rag_GTPases
gptkb:mTORC1
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.1
|
|
gptkbp:memberOf
|
MiT/TFE family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:renal_cell_carcinoma
gptkb:melanoma
lysosomal storage disorders
|
|
gptkbp:orthologInMouse
|
Tfeb
|
|
gptkbp:phosphorylates
|
gptkb:mTORC1
Serine 211
|
|
gptkbp:regulates
|
gptkb:immune_response
apoptosis
cell differentiation
cell proliferation
cell survival
lipid metabolism
inflammation
cellular metabolism
autophagy
mitochondrial biogenesis
stress response
TFEB target genes
cellular clearance
lysosomal biogenesis
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P19484
|
|
gptkbp:bfsParent
|
gptkb:MTOR
gptkb:mammalian_target_of_rapamycin
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TFEB
|