Statements (41)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:component |
gptkb:mTOR_signaling_pathway
|
| gptkbp:discoveredIn |
2004
|
| gptkbp:encodedBy |
DEPTOR gene (for DEPTOR subunit)
MAPKAP1 gene (for mSIN1 subunit) MLST8 gene (for mLST8 subunit) MTOR gene (for mTOR subunit) PRR5 gene (for PROTOR1 subunit) PRR5L gene (for PROTOR2 subunit) RICTOR gene (for RICTOR subunit) |
| gptkbp:foundIn |
eukaryotic cells
|
| https://www.w3.org/2000/01/rdf-schema#label |
mTORC2 complex
|
| gptkbp:inhibitedBy |
PP242
Torin1 rapamycin (acutely) |
| gptkbp:locale |
gptkb:endoplasmic_reticulum
gptkb:plasma_membrane mitochondria |
| gptkbp:regulates |
cell survival
metabolism cell migration cytoskeleton organization AKT phosphorylation PKCĪ± phosphorylation SGK1 phosphorylation |
| gptkbp:relatedTo |
mTORC1 complex
|
| gptkbp:requires |
embryonic development
insulin signaling |
| gptkbp:studiedIn |
cancer research
neurobiology metabolic diseases |
| gptkbp:subunit |
gptkb:DEPTOR
gptkb:PROTOR1 gptkb:PROTOR2 gptkb:RICTOR gptkb:mLST8 gptkb:mSIN1 gptkb:mTOR |
| gptkbp:bfsParent |
gptkb:mSIN1
gptkb:SIN1 |
| gptkbp:bfsLayer |
7
|