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gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:bird
KIAA1303
Regulatory associated protein of mTOR
|
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gptkbp:associatedWith
|
gptkb:cancer
metabolic disorders
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gptkbp:discoveredBy
|
Sabatini lab
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gptkbp:encodes
|
Regulatory-associated protein of mTOR
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gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000141564
57521
|
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gptkbp:expressedIn
|
various human tissues
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gptkbp:firstDescribed
|
2002
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gptkbp:function
|
regulates protein synthesis
regulates cell proliferation
regulates cell survival
component of mTORC1 complex
regulates autophagy
regulates cell growth
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gptkbp:gene
|
gptkb:RPTOR
|
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gptkbp:geneType
|
protein-coding
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gptkbp:HGNC_ID
|
HGNC:30287
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RPTOR
|
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gptkbp:interactsWith
|
gptkb:DEPTOR
gptkb:MLST8
gptkb:PRAS40
gptkb:TSC2
gptkb:mTOR
|
|
gptkbp:involvedIn
|
insulin signaling
nutrient sensing
energy homeostasis
|
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gptkbp:length
|
1335
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
|
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gptkbp:molecularWeight
|
150 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:tuberous_sclerosis
gptkb:cancer
epilepsy
neurodevelopmental disorders
|
|
gptkbp:OMIM
|
609192
|
|
gptkbp:orthologInMouse
|
Rptor
|
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gptkbp:phosphorylates
|
gptkb:S6K1
gptkb:RSK
gptkb:AMPK
|
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gptkbp:RefSeq
|
NM_020761
|
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gptkbp:regulates
|
mTORC1 activity
|
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gptkbp:subcellularLocation
|
gptkb:lysosome
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q8N122
|
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gptkbp:bfsParent
|
gptkb:mLST8
|
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gptkbp:bfsLayer
|
6
|