|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:bird
KIAA1303
Regulatory associated protein of mTOR
|
|
gptkbp:associatedWith
|
gptkb:cancer
metabolic disorders
|
|
gptkbp:discoveredBy
|
Sabatini lab
|
|
gptkbp:encodes
|
Regulatory-associated protein of mTOR
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000141564
57521
|
|
gptkbp:expressedIn
|
various human tissues
|
|
gptkbp:firstDescribed
|
2002
|
|
gptkbp:function
|
regulates protein synthesis
regulates cell proliferation
regulates cell survival
component of mTORC1 complex
regulates autophagy
regulates cell growth
|
|
gptkbp:gene
|
gptkb:RPTOR
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:30287
|
|
gptkbp:interactsWith
|
gptkb:DEPTOR
gptkb:MLST8
gptkb:PRAS40
gptkb:TSC2
gptkb:mTOR
|
|
gptkbp:involvedIn
|
insulin signaling
nutrient sensing
energy homeostasis
|
|
gptkbp:length
|
1335
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
|
|
gptkbp:molecularWeight
|
150 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:tuberous_sclerosis
gptkb:cancer
epilepsy
neurodevelopmental disorders
|
|
gptkbp:OMIM
|
609192
|
|
gptkbp:orthologInMouse
|
Rptor
|
|
gptkbp:phosphorylates
|
gptkb:S6K1
gptkb:RSK
gptkb:AMPK
|
|
gptkbp:RefSeq
|
NM_020761
|
|
gptkbp:regulates
|
mTORC1 activity
|
|
gptkbp:subcellularLocation
|
gptkb:lysosome
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q8N122
|
|
gptkbp:bfsParent
|
gptkb:17q25
gptkb:MLST8
gptkb:P49841
gptkb:mLST8
gptkb:mechanistic_target_of_rapamycin_complex_1
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RPTOR
|