|
gptkbp:instanceOf
|
gptkb:UniProt_accession_number
|
|
gptkbp:alternativeName
|
gptkb:ERBB
gptkb:ERBB1
gptkb:HER1
mENA
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:glioblastoma
colorectal cancer
head and neck cancer
|
|
gptkbp:biologicalProcess
|
cell proliferation
signal transduction
ATP binding
protein tyrosine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:disulfideBond
|
285-296
339-351
375-387
558-567
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000146648
1956
|
|
gptkbp:function
|
gptkb:Receptor_tyrosine_kinase
|
|
gptkbp:gene
|
gptkb:EGFR
|
|
gptkbp:glycosylation
|
N151
N420
N579
N586
|
|
gptkbp:hasIsoform
|
4
|
|
gptkbp:HGNC_ID
|
3236
|
|
gptkbp:inhibitedBy
|
gptkb:brigatinib
gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
gptkb:dacomitinib
gptkb:lapatinib
gptkb:neratinib
gptkb:panitumumab
|
|
gptkbp:InterPro
|
gptkb:IPR001662
gptkb:IPR015789
IPR016245
|
|
gptkbp:KEGGID
|
gptkb:hsa:1956
|
|
gptkbp:ligand
|
gptkb:amphiregulin
gptkb:betacellulin
gptkb:epiregulin
gptkb:epidermal_growth_factor
gptkb:heparin-binding_EGF-like_growth_factor
gptkb:transforming_growth_factor_alpha
|
|
gptkbp:locatedOnChromosome
|
7
|
|
gptkbp:locusType
|
gptkb:7p11.2
|
|
gptkbp:mass
|
134277 Da
|
|
gptkbp:OMIM
|
131550
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
9606
|
|
gptkbp:PDB
|
gptkb:2J6M
gptkb:2RGP
1M17
2GS6
2ITX
3POZ
4HJO
4KRL
5HG7
5JEB
|
|
gptkbp:phosphorylates
|
Y1045
Y1068
Y1148
Y1173
Y992
|
|
gptkbp:protein_name
|
gptkb:Epidermal_growth_factor_receptor
|
|
gptkbp:proteinFamily
|
gptkb:PF00069
gptkb:PF07714
|
|
gptkbp:Reactome
|
gptkb:R-HSA-177929
|
|
gptkbp:refersTo
|
gptkb:Epidermal_growth_factor_receptor
|
|
gptkbp:RefSeq
|
NP_005219.2
|
|
gptkbp:sequence
|
1210
|
|
gptkbp:signalPeptide
|
1-24
|
|
gptkbp:subunit
|
homodimer
heterodimer with ERBB2
heterodimer with ERBB3
heterodimer with ERBB4
|
|
gptkbp:tissue_specificity
|
gptkb:cancer
gptkb:kidney
gptkb:placenta
brain
heart
liver
epithelial tissue
intestine
|
|
gptkbp:transmembraneDomains
|
622-644
|
|
gptkbp:UniGene
|
gptkb:Hs.654510
|
|
gptkbp:UniProtID
|
gptkb:P42338
|
|
gptkbp:UniProtReviewed
|
Yes
|
|
gptkbp:bfsParent
|
gptkb:PIK3CB
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P42338
|