P42338

GPTKB entity

Statements (96)
Predicate Object
gptkbp:instanceOf UniProt accession number
gptkbp:alternativeName gptkb:ERBB
gptkb:ERBB1
gptkb:HER1
mENA
gptkbp:associatedWith gptkb:cancer
gptkb:glioblastoma
colorectal cancer
head and neck cancer
gptkbp:biologicalProcess cell proliferation
signal transduction
ATP binding
protein tyrosine kinase activity
gptkbp:cellularComponent gptkb:plasma_membrane
gptkbp:disulfideBond 285-296
339-351
375-387
558-567
gptkbp:Entrez_Gene_ID gptkb:ENSG00000146648
1956
gptkbp:function gptkb:Receptor_tyrosine_kinase
gptkbp:gene gptkb:EGFR
gptkbp:glycosylation N151
N420
N579
N586
gptkbp:hasIsoform 4
gptkbp:HGNC_ID 3236
https://www.w3.org/2000/01/rdf-schema#label P42338
gptkbp:inhibitedBy gptkb:brigatinib
gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
gptkb:dacomitinib
gptkb:lapatinib
gptkb:neratinib
gptkb:panitumumab
gptkbp:InterPro gptkb:IPR001662
gptkb:IPR015789
IPR016245
gptkbp:KEGGID gptkb:hsa:1956
gptkbp:ligand gptkb:amphiregulin
gptkb:betacellulin
gptkb:epiregulin
gptkb:epidermal_growth_factor
gptkb:heparin-binding_EGF-like_growth_factor
gptkb:transforming_growth_factor_alpha
gptkbp:locatedOnChromosome 7
gptkbp:locusType gptkb:7p11.2
gptkbp:mass 134277 Da
gptkbp:OMIM 131550
gptkbp:organism gptkb:Homo_sapiens
9606
gptkbp:PDB gptkb:2J6M
gptkb:2RGP
1M17
2GS6
2ITX
3POZ
4HJO
4KRL
5HG7
5JEB
gptkbp:phosphorylates Y1045
Y1068
Y1148
Y1173
Y992
gptkbp:protein_name gptkb:Epidermal_growth_factor_receptor
gptkbp:proteinFamily gptkb:PF00069
gptkb:PF07714
gptkbp:Reactome gptkb:R-HSA-177929
gptkbp:refersTo gptkb:Epidermal_growth_factor_receptor
gptkbp:RefSeq NP_005219.2
gptkbp:sequence 1210
gptkbp:signalPeptide 1-24
gptkbp:subunit homodimer
heterodimer with ERBB2
heterodimer with ERBB3
heterodimer with ERBB4
gptkbp:tissue_specificity gptkb:cancer
gptkb:kidney
gptkb:placenta
brain
heart
liver
epithelial tissue
intestine
gptkbp:transmembraneDomains 622-644
gptkbp:UniGene gptkb:Hs.654510
gptkbp:UniProtID gptkb:P42338
gptkbp:UniProtReviewed Yes
gptkbp:bfsParent gptkb:PIK3CB
gptkbp:bfsLayer 5