|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:ERBB
gptkb:ERBB1
gptkb:HER1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:glioblastoma
colorectal cancer
head and neck cancer
|
|
gptkbp:biologicalProcess
|
cell proliferation
signal transduction
receptor tyrosine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:domain
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:Entrez_Gene_ID
|
ENSP00000275493
|
|
gptkbp:expressedIn
|
gptkb:breast
gptkb:cancer
gptkb:skin
gptkb:kidney
liver
colon
epithelial tissues
|
|
gptkbp:fullName
|
gptkb:Epidermal_growth_factor_receptor
|
|
gptkbp:function
|
activates downstream signaling pathways
binds epidermal growth factor
|
|
gptkbp:gene
|
gptkb:EGFR
|
|
gptkbp:GO_term
|
gptkb:GO:0005006
GO:0005886
GO:0005524
GO:0004672
|
|
gptkbp:HGNC_ID
|
3236
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P15056
|
|
gptkbp:InterPro
|
gptkb:IPR001662
gptkb:IPR015789
IPR003599
|
|
gptkbp:KEGGID
|
gptkb:hsa:1956
|
|
gptkbp:length
|
1210
|
|
gptkbp:locatedOnChromosome
|
gptkb:7p11.2
|
|
gptkbp:mass_(Da)
|
134277
|
|
gptkbp:OMIM
|
131550
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:chicken_EGFR
gptkb:dog_EGFR
gptkb:mouse_Egfr
gptkb:rat_Egfr
gptkb:zebrafish_egfra
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:7AEM
1M17
2GS6
2ITX
3POZ
4KRL
5HG7
5JEB
5UG9
6JXT
7JXH
6VHN
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
ubiquitination
|
|
gptkbp:proteinFamily
|
gptkb:PF00069
gptkb:PF07714
|
|
gptkbp:Reactome
|
gptkb:R-HSA-177929
|
|
gptkbp:RefSeq
|
NP_005219.2
|
|
gptkbp:subunit
|
homodimer
monomer
heterodimer with ERBB2
|
|
gptkbp:targetOfDrug
|
gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
gptkb:dacomitinib
gptkb:lapatinib
gptkb:panitumumab
|
|
gptkbp:UniGene
|
Hs.654508
|
|
gptkbp:UniProtID
|
gptkb:P15056
|
|
gptkbp:bfsParent
|
gptkb:BRAF
gptkb:BRAF_gene
|
|
gptkbp:bfsLayer
|
5
|