JAK-STAT signaling pathway

GPTKB entity

Predicate	Object
gptkbp:instanceOf	biological pathway
gptkbp:activatedBy	cytokines growth factors
gptkbp:associatedWith	gptkb:cancer autoimmune diseases cell growth immune response hematopoiesis
gptkbp:discoveredBy	gptkb:George_Stark gptkb:Ian_M._Kerr gptkb:James_E._Darnell
gptkbp:firstDescribed	1990s
gptkbp:foundIn	animals
https://www.w3.org/2000/01/rdf-schema#label	JAK-STAT signaling pathway
gptkbp:involves	gptkb:JAK2 gptkb:STAT1 gptkb:JAK1 gptkb:Janus_kinases gptkb:STAT2 gptkb:STAT4 gptkb:STAT5A gptkb:STAT5B gptkb:STAT6 gptkb:STAT_proteins gptkb:TYK2 gptkb:STAT3 gptkb:JAK3
gptkbp:KEGGID	hsa04630
gptkbp:Reactome	R-HSA-6785807
gptkbp:regulates	gptkb:PIAS_proteins gptkb:SOCS_proteins gptkb:protein_tyrosine_phosphatases gene expression
gptkbp:step	transcriptional activation DNA binding JAK activation STAT dimerization STAT phosphorylation ligand binding to receptor nuclear translocation of STATs
gptkbp:target	gptkb:fedratinib gptkb:ruxolitinib gptkb:tofacitinib gptkb:upadacitinib gptkb:baricitinib JAK inhibitors STAT inhibitors
gptkbp:bfsParent	gptkb:EGFR_gene gptkb:P15056 gptkb:CIS_(gene) gptkb:ALK gptkb:NP_005334.1 gptkb:CISH gptkb:PDGFRα
gptkbp:bfsLayer	6