Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
ABC transporter |
| gptkbp:alternativeName |
gptkb:SERT
gptkb:serotonin_transporter |
| gptkbp:associatedWith |
gptkb:depression
gptkb:obsessive-compulsive_disorder anxiety |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:encodedBy |
gptkb:SLC6A4
|
| gptkbp:function |
transports serotonin from synaptic cleft to presynaptic neuron
|
| gptkbp:hasPolymorphism |
gptkb:5-HTTLPR
|
| https://www.w3.org/2000/01/rdf-schema#label |
5-HTT
|
| gptkbp:inhibitedBy |
gptkb:tricyclic_antidepressants
gptkb:selective_serotonin_reuptake_inhibitors |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_17q11.2
|
| gptkbp:location |
central nervous system
platelets presynaptic membrane |
| gptkbp:molecularWeight |
~70 kDa
|
| gptkbp:target |
antidepressant drugs
|
| gptkbp:UniProtID |
gptkb:P31645
|
| gptkbp:bfsParent |
gptkb:ENSG00000105851
gptkb:ENSG00000133703 |
| gptkbp:bfsLayer |
6
|