doxepin

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf antidepressant
gptkbp:approvedBy 1969
gptkbp:ATCCode gptkb:N06AA12
gptkbp:brand gptkb:Adapin
gptkb:Silenor
gptkb:Sinequan
gptkbp:CASNumber gptkb:1668-19-5
gptkbp:category benzodiazepine
antihistamine
antidepressant
hypnotic
tricyclic compound
gptkbp:chemicalFormula gptkb:C19H21NO
gptkbp:contraindication urinary retention
narrow angle glaucoma
gptkbp:discoveredBy gptkb:Pfizer
gptkbp:eliminationHalfLife 8–24 hours
gptkbp:excretion urine
gptkbp:hasEnantiomer (E)-doxepin
(Z)-doxepin
https://www.w3.org/2000/01/rdf-schema#label doxepin
gptkbp:KEGGID D07816
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction antihistamine
norepinephrine reuptake inhibitor
gptkbp:MedlinePlusID a682338
gptkbp:metabolism liver
gptkbp:molecularWeight 279.38 g/mol
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 76%
gptkbp:PubChem_CID CHEMBL651
3157
DB01142
gptkbp:relatedTo gptkb:amitriptyline
gptkb:imipramine
gptkb:nortriptyline
gptkbp:routeOfAdministration oral
topical
gptkbp:sideEffect constipation
blurred vision
weight gain
drowsiness
dry mouth
urinary retention
gptkbp:UNII MN3L5RMN02
gptkbp:usedFor gptkb:depression
anxiety
pruritus
insomnia
gptkbp:bfsParent gptkb:tricyclic_antidepressants
gptkbp:bfsLayer 6