|
gptkbp:instanceOf
|
gptkb:antidepressant
|
|
gptkbp:approvedBy
|
1969
|
|
gptkbp:ATCCode
|
gptkb:N06AA12
|
|
gptkbp:brand
|
gptkb:Adapin
gptkb:Silenor
gptkb:Sinequan
|
|
gptkbp:CASNumber
|
gptkb:1668-19-5
|
|
gptkbp:category
|
gptkb:antidepressant
gptkb:antihistamine
gptkb:benzodiazepine
gptkb:hypnotic
tricyclic compound
|
|
gptkbp:chemicalFormula
|
gptkb:C19H21NO
|
|
gptkbp:contraindication
|
urinary retention
narrow angle glaucoma
|
|
gptkbp:discoveredBy
|
gptkb:Pfizer
|
|
gptkbp:eliminationHalfLife
|
8–24 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasEnantiomer
|
(E)-doxepin
(Z)-doxepin
|
|
gptkbp:KEGGID
|
D07816
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
gptkb:norepinephrine_reuptake_inhibitor
gptkb:antihistamine
|
|
gptkbp:MedlinePlusID
|
a682338
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
279.38 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
76%
|
|
gptkbp:PubChem_CID
|
CHEMBL651
3157
DB01142
|
|
gptkbp:relatedTo
|
gptkb:amitriptyline
gptkb:imipramine
gptkb:nortriptyline
|
|
gptkbp:routeOfAdministration
|
oral
topical
|
|
gptkbp:sideEffect
|
constipation
blurred vision
weight gain
drowsiness
dry mouth
urinary retention
|
|
gptkbp:UNII
|
MN3L5RMN02
|
|
gptkbp:usedFor
|
gptkb:depression
anxiety
pruritus
insomnia
|
|
gptkbp:bfsParent
|
gptkb:Lumivia
|
|
gptkbp:bfsLayer
|
7
|
|
http://www.w3.org/2000/01/rdf-schema#label
|
doxepin
|