|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:5-HTT
gptkb:solute_carrier_family_6_member_4
gptkb:serotonin_transporter
|
|
gptkbp:associatedWith
|
gptkb:depression
gptkb:autism_spectrum_disorder
gptkb:obsessive-compulsive_disorder
anxiety
|
|
gptkbp:component
|
integral component of plasma membrane
|
|
gptkbp:encodedBy
|
gptkb:SLC6A4_gene
|
|
gptkbp:Entrez_Gene_ID
|
6532
|
|
gptkbp:expressedIn
|
central nervous system
platelets
intestine
|
|
gptkbp:function
|
serotonin:sodium symporter activity
serotonin reuptake
|
|
gptkbp:GOProcess
|
serotonin uptake
|
|
gptkbp:hasPolymorphism
|
gptkb:5-HTTLPR
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SLC6A4 protein
|
|
gptkbp:inhibitedBy
|
gptkb:citalopram
gptkb:escitalopram
gptkb:paroxetine
gptkb:sertraline
gptkb:venlafaxine
gptkb:MDMA
gptkb:amitriptyline
gptkb:imipramine
gptkb:fluoxetine
cocaine
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q11.2
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:memberOf
|
gptkb:solute_carrier_family
|
|
gptkbp:molecularWeight
|
approximately 70 kDa
|
|
gptkbp:OMIM
|
182138
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
5I6X
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:regulates
|
epigenetic modification
transcriptional regulation by stress
|
|
gptkbp:significance
|
pharmacogenomics of antidepressant response
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structureType
|
integral membrane protein
|
|
gptkbp:target
|
gptkb:tricyclic_antidepressants
gptkb:MDMA
gptkb:selective_serotonin_reuptake_inhibitors
cocaine
|
|
gptkbp:transmembraneDomains
|
12
|
|
gptkbp:UniProtID
|
gptkb:P31645
|
|
gptkbp:bfsParent
|
gptkb:ENSG00000133703
|
|
gptkbp:bfsLayer
|
6
|