|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:SERT
gptkb:serotonin_transporter
|
|
gptkbp:associatedWith
|
gptkb:depression
gptkb:obsessive-compulsive_disorder
anxiety
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:encodedBy
|
gptkb:SLC6A4
|
|
gptkbp:expressedIn
|
central nervous system
platelets
|
|
gptkbp:function
|
serotonin reuptake
|
|
gptkbp:hasPolymorphism
|
gptkb:5-HTTLPR
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
5HTT
|
|
gptkbp:inhibitedBy
|
gptkb:tricyclic_antidepressants
gptkb:SSRIs
|
|
gptkbp:involvedIn
|
gptkb:autism_spectrum_disorder
bipolar disorder
ADHD
drug addiction
synaptic transmission
pulmonary hypertension
learning and memory
fibromyalgia
irritable bowel syndrome
anxiety regulation
sleep regulation
stress response
appetite regulation
alcohol dependence
mood regulation
pain perception
nicotine dependence
cardiovascular function
cocaine dependence
platelet aggregation
|
|
gptkbp:locatedIn
|
presynaptic neuron membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17q11.2
|
|
gptkbp:memberOf
|
gptkb:solute_carrier_family
|
|
gptkbp:molecularWeight
|
~70 kDa
|
|
gptkbp:OMIM
|
182138
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:phosphorylates
|
gptkb:PKC
PKA
|
|
gptkbp:regulates
|
serotonin signaling
|
|
gptkbp:structure
|
12 transmembrane domains
|
|
gptkbp:target
|
antidepressant drugs
|
|
gptkbp:transportation
|
serotonin
|
|
gptkbp:UniProtID
|
gptkb:P31645
|
|
gptkbp:bfsParent
|
gptkb:ENSG00000133703
|
|
gptkbp:bfsLayer
|
6
|