|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:5-HTT
gptkb:SERT
gptkb:solute_carrier_family_6_member_4
|
|
gptkbp:associatedWith
|
gptkb:depression
gptkb:autism_spectrum_disorder
gptkb:obsessive-compulsive_disorder
anxiety
|
|
gptkbp:discoveredBy
|
gptkb:Kuhar_et_al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodes
|
gptkb:serotonin_transporter
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000108576
6532
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:placenta
brain
gastrointestinal tract
|
|
gptkbp:function
|
serotonin reuptake
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasClinicalTest
|
pharmacogenetic testing
|
|
gptkbp:hasPolymorphism
|
gptkb:5-HTTLPR
|
|
gptkbp:hasPromoterPolymorphism
|
gptkb:5-HTTLPR
|
|
gptkbp:hasRatHomolog
|
gptkb:Slc6a4
|
|
gptkbp:HGNC_ID
|
11050
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SLC6A4
|
|
gptkbp:involvedIn
|
synaptic transmission
neurotransmitter transport
stress response
mood regulation
|
|
gptkbp:length
|
14 exons
630 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q11.2
|
|
gptkbp:memberOf
|
gptkb:solute_carrier_family_6
|
|
gptkbp:mRNATranscript
|
gptkb:NM_001045
|
|
gptkbp:mutationAssociatedWith
|
psychiatric disorders
|
|
gptkbp:OMIM
|
182138
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:orthologInMouse
|
gptkb:Slc6a4
|
|
gptkbp:orthologInZebrafish
|
gptkb:slc6a4a
gptkb:slc6a4b
|
|
gptkbp:pathway
|
neuroactive ligand-receptor interaction
serotonin uptake pathway
|
|
gptkbp:product
|
gptkb:SERT
|
|
gptkbp:regulates
|
serotonergic signaling
|
|
gptkbp:target
|
gptkb:tricyclic_antidepressants
gptkb:selective_serotonin_reuptake_inhibitors
|
|
gptkbp:transportation
|
serotonin
|
|
gptkbp:UniProtID
|
gptkb:P31645
|
|
gptkbp:bfsParent
|
gptkb:ENSG00000105851
gptkb:ENSG00000163945
gptkb:chromosome_17
gptkb:ENSG00000133703
gptkb:solute_carrier_family
|
|
gptkbp:bfsLayer
|
6
|