monoamine oxidase inhibitors

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:drug
gptkbp:abbreviation	MAOIs
gptkbp:approvedBy	1950s
gptkbp:ATCCode	gptkb:N06AF
gptkbp:category	gptkb:enzyme antidepressant psychiatric medication
gptkbp:contraindication	gptkb:tricyclic_antidepressants gptkb:SSRIs tyramine-rich foods
gptkbp:discoveredIn	1950s
gptkbp:effect	increase levels of dopamine increase levels of norepinephrine increase levels of serotonin
gptkbp:eliminatedIn	urine
gptkbp:example	gptkb:isocarboxazid gptkb:phenelzine gptkb:rasagiline gptkb:tranylcypromine gptkb:selegiline
https://www.w3.org/2000/01/rdf-schema#label	monoamine oxidase inhibitors
gptkbp:interactsWith	gptkb:dextromethorphan gptkb:linezolid gptkb:meperidine sympathomimetic drugs
gptkbp:legalStatus	Rx-only
gptkbp:mechanismOfAction	inhibit monoamine oxidase enzyme
gptkbp:metabolism	liver
gptkbp:notableFor	first class of antidepressants
gptkbp:prescriptionStatus	prescription only
gptkbp:replacedBy	gptkb:SSRIs gptkb:SNRIs
gptkbp:riskFactor	drug-drug interaction drug-food interaction
gptkbp:routeOfAdministration	oral transdermal
gptkbp:sideEffect	gptkb:orthostatic_hypotension gptkb:serotonin_syndrome weight gain sexual dysfunction hypertensive crisis
gptkbp:target	gptkb:monoamine_oxidase_A gptkb:monoamine_oxidase_B
gptkbp:usedFor	gptkb:Parkinson's_disease gptkb:depression anxiety disorders
gptkbp:usedIn	treatment-resistant depression atypical depression
gptkbp:bfsParent	gptkb:Ritalin gptkb:Zyvox
gptkbp:bfsLayer	5