selective serotonin reuptake inhibitors

GPTKB entity

Predicate	Object
gptkbp:instanceOf	class of antidepressant medications
gptkbp:abbreviation	gptkb:SSRIs
gptkbp:alternativeTo	gptkb:tricyclic_antidepressants gptkb:monoamine_oxidase_inhibitors
gptkbp:approvalYear	1987
gptkbp:approvedBy	gptkb:fluoxetine
gptkbp:contraindication	concurrent use with MAO inhibitors allergy to SSRIs
gptkbp:discoveredIn	1970s
gptkbp:drugInteraction	gptkb:warfarin gptkb:NSAIDs other serotonergic drugs
gptkbp:eliminatedIn	kidneys
gptkbp:example	gptkb:citalopram gptkb:escitalopram gptkb:fluvoxamine gptkb:paroxetine gptkb:sertraline gptkb:fluoxetine
gptkbp:form	gptkb:tablet gptkb:water capsule
https://www.w3.org/2000/01/rdf-schema#label	selective serotonin reuptake inhibitors
gptkbp:improves	serotonin levels in synaptic cleft
gptkbp:mechanismOfAction	inhibit reuptake of serotonin in the brain
gptkbp:metabolism	liver
gptkbp:notEffectiveAgainst	schizophrenia bipolar mania
gptkbp:pregnancyCategory	varies by drug
gptkbp:prescribes	psychiatrists primary care physicians
gptkbp:regulates	prescription only
gptkbp:riskFactor	gptkb:serotonin_syndrome
gptkbp:sideEffect	nausea headache weight gain insomnia dry mouth sexual dysfunction increased risk of suicidal thoughts in young people
gptkbp:usedFor	gptkb:obsessive-compulsive_disorder gptkb:panic_disorder gptkb:post-traumatic_stress_disorder gptkb:major_depressive_disorder gptkb:bulimia_nervosa anxiety disorders
gptkbp:withdrawalSymptom	dizziness sleep disturbances irritability flu-like symptoms
gptkbp:bfsParent	gptkb:OCD gptkb:selective_mutism
gptkbp:bfsLayer	5