|
gptkbp:instanceOf
|
gptkb:drug
opioid
|
|
gptkbp:antidote
|
gptkb:naloxone
|
|
gptkbp:approvalYear
|
1977
1995
|
|
gptkbp:approvedBy
|
gptkb:Germany
gptkb:United_States
|
|
gptkbp:ATCCode
|
N02AX02
|
|
gptkbp:availableOn
|
gptkb:government_agency
gptkb:tablet
capsule
injection
suppository
|
|
gptkbp:brand
|
gptkb:Conzip
gptkb:Rybix_ODT
gptkb:Tramal
gptkb:Ultram
gptkb:Zydol
gptkb:Ryzolt
|
|
gptkbp:CASNumber
|
27203-92-5
|
|
gptkbp:chemicalFormula
|
C16H25NO2
|
|
gptkbp:contraindication
|
gptkb:monoamine_oxidase_inhibitors
severe respiratory depression
acute intoxication with alcohol
|
|
gptkbp:controlledSubstanceSchedule
|
Schedule IV (US)
|
|
gptkbp:developedBy
|
gptkb:Grünenthal_GmbH
|
|
gptkbp:discoveredBy
|
gptkb:Grünenthal_GmbH
|
|
gptkbp:discoveredIn
|
1962
|
|
gptkbp:excretion
|
kidneys
|
|
gptkbp:halfLife
|
6.3 hours
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tramadol
|
|
gptkbp:interactsWith
|
gptkb:beer
gptkb:tricyclic_antidepressants
gptkb:SSRIs
MAOIs
other opioids
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
norepinephrine reuptake inhibitor
mu-opioid receptor agonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:overdoseSymptoms
|
cardiac arrest
coma
seizures
respiratory depression
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:riskFactor
|
gptkb:serotonin_syndrome
addiction
respiratory depression
dependence
|
|
gptkbp:routeOfAdministration
|
oral
intramuscular
subcutaneous
intravenous
rectal
|
|
gptkbp:sideEffect
|
nausea
vomiting
constipation
dizziness
headache
sweating
seizures
drowsiness
dry mouth
|
|
gptkbp:usedFor
|
pain management
moderate pain
moderately severe pain
|
|
gptkbp:bfsParent
|
gptkb:Schedule_IV
gptkb:Shahin_Najafi
|
|
gptkbp:bfsLayer
|
6
|